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The MLB regular-season game between the San Diego Padres and Seattle Mariners is scheduled for May 15, 2026, at T-Mobile Park in Seattle, WA. Broadcasted on Seam, this matchup features the Padres as the away team and the Mariners at home. Our picks predict a final score of Seattle 4.45 to San Diego 3.33 with Seattle favored on the moneyline but the Padres holding a 54.3% probability to cover the +1.5 spread. Hit rates for point spread bets have been favorable recently, supporting these betting tips.
Seattle's left-handed starting pitcher will face San Diego's hitters, who have a moderate performance against lefties, while Seattle's offense has shown resilience against right-handed pitching. Our prediction model has yielded profitable results in the last 10 MLB games, particularly in the point spread market with a notable EV and hit rate. For more detailed MLB picks and analysis, visit MLB Picks and Predictions.
PHIJ. Luzardo (L) 39-3331% -168Bet105 | |||||||
BOSP. Tolle (L) 29-4047% +105Everygame | |||||||
WSHF. Griffin (L) 38-3514% -129Bet105 | |||||||
NYYG. Cole (R) 43-2720% -137Everygame | |||||||
CINB. Singer (R) 34-3733% +110Everygame | |||||||
ATLG. Holmes (R) 46-2520% -161BetOnline | |||||||
MILR. Gasser (L) 43-2633% -135Heritage | |||||||
STLA. Pallante (R) 39-3126% -113Bet105 | |||||||
![]() CHCE. Cabrera (R) 38-3519% -190Everygame | |||||||
![]() TEXK. Rocker (R) 35-3724% -123Bet105 | |||||||
HOUH. Brown (R) 33-4139% -171Bet105 | |||||||
SEAL. Gilbert (R) 37-3626% -145Everygame | |||||||
![]() ATHJ. Perkins (R) 36-3647% -135BetAnything | |||||||
![]() AZM. Kelly (R) 37-3539% -106Bet105 | |||||||
LADJ. Wrobleski (L) 46-2726% -142BetOnline | |||||||
CINN. Lodolo (L) 34-37- +115MyBookie | |||||||
PHIA. Painter (R) 39-33- -110BetOnline | |||||||
WSHZ. Littell (R) 38-35- -118MyBookie | |||||||
HOUP. Lambert (R) 33-41- -105BetOnline | |||||||
LADS. Ohtani (R) 46-27- -185BetOnline | |||||||
![]() AZE. Rodriguez (L) 37-35- -160BetOnline | |||||||
BOSJ. Bennett (L) 29-40- -121BetOnline | |||||||
NYYC. Rodón (L) 43-27- -160BetOnline | |||||||
ATLJ. Ritchie (R) 46-25- -146BetOnline | |||||||
MILB. Sproat (R) 43-26- -120BetOnline | |||||||
![]() CHCJ. Assad (R) 38-35- -180BetOnline | |||||||
SEAG. Kirby (R) 37-36- -140BetOnline | |||||||
![]() ATHA. Civale (R) 36-36- +104BetOnline |