San Diego Padres vs Toronto Blue Jays - Game Preview

The San Diego Padres are set to face off against the Toronto Blue Jays at the Rogers Centre in Toronto, Ontario, on May 22, 2025, at 1:07 PM ET. This matchup presents an interesting dynamic as both teams come off contrasting performances in their last matchup on May 21, where the Blue Jays dominated with a 14-0 victory. The game will be broadcasted live on SDPA. For bettors, the Padres, despite being favorites, are priced at -120 on the Moneyline, while the Blue Jays are at +100. The point spread favors Toronto by 1.5 points. Notably, the Padres have a 26-21-0 record against the spread, while the Blue Jays lead the league with a 30-18-0 record, which you can see on our MLB standings page. Starting pitchers Stephen Kolek (R) for San Diego, boasting a 2.328 ERA, and Bowden Francis (R) for Toronto, with a 5.633 ERA, will play crucial roles. Kolek's strong performance could be a game-changer. Both teams exhibit solid fielding metrics, with Toronto slightly edging San Diego in fielding percentage. The Padres' recent struggles and Toronto's home advantage suggest a competitive game, but Toronto's superior ATS record and recent form make them a compelling choice for bettors.