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The upcoming Saturday football clash on November 29, 2025, between the Iowa State Cyclones and Oklahoma State Cowboys at Boone Pickens Stadium in Stillwater, OK, promises an intense battle in the 2025-26 NCAAF season. Iowa State enters this game as the favorite with a -13.5 point spread, reflecting their strong offensive output of 28.09 points per game. Oklahoma State, while underdogs, boasts a robust defense that allows just 34.55 points per game, setting the stage for a strategic showdown.
Starting quarterbacks will play a pivotal role, with Iowa State's QB leading an offense that averages 231.27 passing yards per game, facing Oklahoma State's defense that yields 265.09 passing yards. Conversely, Oklahoma State's QB will challenge the Cyclones' defense, which limits opponents to 220 passing yards. The run game is equally critical, with Iowa State's 39.09 rushing yards per game tested against a Cowboys' defense allowing 37.27 rushing yards.
Betting trends suggest a competitive match with an over/under set at 46 points, indicating a moderately scoring game. The Cowboys' home advantage at Boone Pickens Stadium, combined with their defensive strengths, could keep the game close despite the spread. The Cyclones' ability to protect the quarterback against Oklahoma State's pass rush will be crucial.
The last matchup on September 23, 2023, saw the Cyclones narrowly defeating the Cowboys 34-27, a game that favored Iowa State ATS and went over the total points. This historical context adds depth to the betting insights for this encounter. Fans can catch the game on ESPNU, making it accessible for viewers eager to see this high-stakes rivalry.
For bettors looking to capitalize on this game, understanding these betting trends and game insights is key. The best odds currently offer Oklahoma State at +13.5 with a -113 price and Iowa State at -13.5 with -107 odds at Caesars. The total points line sits at 46, with the over favored at -112. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Check out the detailed statistics and recent performances to make an informed decision, and explore the Iowa State Cyclones vs Oklahoma State Cowboys betting trends for a winning edge.
West Virginia 4-773% +24½ -130BetMGM | |||||||
![]() Florida Atlantic 4-782% +7 -105BetMGM | |||||||
Louisville 7-415% -2½ -110Bet365 | |||||||
![]() South Carolina 3-732% -2½ -110Bet365 | |||||||
![]() #15Michigan 9-273% +10½ -122FanDuel | |||||||
![]() #22Pittsburgh 8-363% +7 -110Caesars | |||||||
Central Michigan 7-454% +11½ -115FanDuel | |||||||
Miami (OH) 6-550% -17½ -105Bet365 | |||||||
![]() Kansas State 5-635% -17 -110Bet365 | |||||||
Baylor 5-643% -2½ -114Caesars | |||||||
Oklahoma State 1-1081% +14 -110BetMGM | |||||||
![]() Delaware 5-630% -3½ -118FanDuel | |||||||
![]() Sam Houston State 2-971% +11½ -113BetRivers | |||||||
#11Brigham Young 10-166% -17½ -106FanDuel | |||||||
Marshall 5-622% -10 -110Bet365 | |||||||
![]() Old Dominion 8-327% -27½ -110Bet365 | |||||||
![]() Missouri State 7-429% -2½ -110Bet365 | |||||||
![]() Jacksonville State 7-427% +3 -115BetMGM | |||||||
Appalachian State 5-643% -1½ -102FanDuel | |||||||
Syracuse 3-840% +3 -108BetRivers | |||||||
![]() Tulsa 4-745% -8½ -110Bet365 | |||||||
Texas State 5-640% -8½ -115FanDuel | |||||||
![]() Louisiana 5-620% -8½ -114SugarHouse | |||||||
New Mexico State 4-767% -3½ -105BetMGM | |||||||
#19Tennessee 8-336% -2½ -112FanDuel | |||||||
![]() Duke 6-546% -1 -110Bet365 | |||||||
Rutgers 5-694% +14 -118BetRivers | |||||||
![]() #8Oklahoma 9-264% -10½ -110Bet365 | |||||||
![]() UTSA 6-537% -7 -120SugarHouse | |||||||
TCU 6-487% -3 -124BetRivers | |||||||
Southern Miss 7-450% -6 -118SugarHouse | |||||||
![]() Arkansas 2-980% +4 -112Caesars | |||||||
Minnesota 6-534% +2½ -115Caesars | |||||||
![]() Washington 8-373% +7 -110Bet365 | |||||||
![]() Liberty 4-779% +2½ -115SugarHouse | |||||||
![]() Coastal Carolina 6-587% +22 -109Caesars | |||||||
Florida 3-827% -½ -115SugarHouse | |||||||
![]() Washington State 5-647% -13 -115BetRivers | |||||||
![]() South Florida 8-35% -28 -107Caesars | |||||||
Michigan State 3-895% -3½ -114FanDuel | |||||||
![]() #18Virginia 9-219% -8 +100Bet365 | |||||||
![]() North Carolina State 6-524% -7 -110Caesars | |||||||
Auburn 5-682% +6 -113BetRivers | |||||||
#24Tulane 9-28% -29½ -115BetMGM | |||||||
Illinois 7-413% -7 -110Bet365 | |||||||
#17USC 8-242% -21½ -108FanDuel | |||||||
![]() California 6-548% +13½ -110Bet365 | |||||||
![]() Nevada 3-874% +7½ -110Bet365 | |||||||
![]() San Jose State 3-886% +3½ -109Caesars | |||||||
Stanford 4-778% +32½ -110BetMGM | |||||||
![]() Hawaii 7-417% -7½ -110Caesars | |||||||
![]() Massachusetts 0-1214 +14½ -110Bet365 | |||||||
Eastern Michigan 4-821 +10 -105BetMGM | |||||||
![]() Memphis 8-417 -3½ -112Caesars | |||||||
Buffalo 5-726 +7½ -120FanDuel | |||||||
![]() Mississippi State 5-719 +8 -127SugarHouse | |||||||
Nebraska 7-516 +6 +100Caesars | |||||||
![]() Northern Illinois 3-931 -4½ -115Bet365 | |||||||
![]() Kansas 5-721 +10½ -115Caesars | |||||||
![]() Colorado State 2-1021 +2½ -105FanDuel | |||||||
![]() #23Georgia Tech 9-39 +16½ -105BetMGM | |||||||
![]() New Mexico 9-323 +1½ -115BetMGM | |||||||
![]() North Texas 11-152 -20 -112SugarHouse | |||||||
![]() Utah State 6-624 +1½ -105FanDuel | |||||||
![]() #16Texas 9-327 +2½ +100Caesars | |||||||
![]() Purdue 2-103 +29 -113BetRivers | |||||||
![]() #20Arizona State 8-47 +2 -107Caesars |
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