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Get ready for Saturday football as the Pittsburgh Panthers vs Syracuse Orange meet on October 18, 2025. Our betting trends and game insights break down this upcoming NCAAF clash at JMA Wireless Dome in Syracuse, NY, airing on ACC Network. Kickoff is at 7:30 p.m. ET.
The Panthers are set to start their first-string quarterback, who is listed as questionable with a minor shoulder issue but is expected to play. Syracuse will counter with its veteran signal caller under center. In their October 24th, 2024 41-13 victory, Pittsburgh dominated 41-13, showcasing its aerial attack.
Offensively, Pittsburgh averages 309.3 passing yards per game while Syracuse’s defense allows 291.2. The Orange put up 320.5 yards through the air but surrender 230.2 on average. On the ground, Syracuse rushes for 111.8 yards versus Pittsburgh allowing just 82.2, while the Panthers churn out 122.5 yards on the ground facing a run defense yielding 157.7. Pittsburgh gives up 2.8 sacks per contest against Syracuse’s 1.3 sacks, so pass protection and rush advantage could sway the line.
The Panthers are 4-2 against the spread while the Orange sit at 3-2-1 ATS, as shown on our NCAAF standings page. Pittsburgh is favored by 10.5 points (-115 at Caesars) with a total of 54.5 (Over -118, Under -104). Given the Panthers’ balanced attack and Syracuse’s defensive lapses, the best bet is Pittsburgh -10.5. Ready to bet smarter? Start your OddsTrader Turbo subscription or lock in your wager at Caesars.
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![]() Sam Houston State 0-664% +3 -121BetRivers | |||||||
East Carolina 3-365% -17 -109BetRivers | |||||||
![]() #2Miami (FL) 5-042% -13½ -110Caesars | |||||||
Minnesota 4-240% +8½ -112FanDuel | |||||||
![]() Utah State 3-330% -3½ -104FanDuel | |||||||
![]() California 4-241% -9½ -118BetRivers | |||||||
Miami (OH) 3-30% -12½ -115FanDuel | |||||||
![]() Boston College 1-577% -1½ -110Bet365 | |||||||
![]() Duke 4-282% -1½ -110Caesars | |||||||
Bowling Green 3-331% -3½ -120FanDuel | |||||||
![]() #17Vanderbilt 5-157% -2½ -110Caesars | |||||||
![]() Michigan 4-253% -5½ -115BetMGM | |||||||
![]() Houston 5-150% +1½ -115BetMGM | |||||||
TCU 4-247% -2½ -121SugarHouse | |||||||
![]() Tulane 5-122% -9½ -110Bet365 | |||||||
![]() South Carolina 3-375% +6 -117SugarHouse | |||||||
UCF 3-325% -7 -112BetRivers | |||||||
![]() Toledo 3-343% -26½ -110Caesars | |||||||
![]() Massachusetts 0-6100% +17 -110Caesars | |||||||
![]() Louisiana-Monroe 3-3100% +6½ -110BetRivers | |||||||
![]() Northwestern 4-230% -3 -113Caesars | |||||||
Appalachian State 4-20% -10½ -105FanDuel | |||||||
![]() Ohio 3-30% -11 -110Caesars | |||||||
![]() James Madison 5-127% -1½ -105BetMGM | |||||||
![]() Charlotte 1-5100% +11½ -110Caesars | |||||||
![]() Clemson 3-331% -8½ -113SugarHouse | |||||||
![]() #3Indiana 6-024% -26½ -115BetMGM | |||||||
Marshall 3-367% +3 -114BetRivers | |||||||
Ball State 2-40% -1½ +100BetMGM | |||||||
![]() Boise State 4-257% -11½ -110BetMGM | |||||||
![]() North Texas 5-130% -4 -110Caesars | |||||||
![]() #9Georgia 5-153% -7 -115BetMGM | |||||||
![]() Arkansas 2-480% +8 -115SugarHouse | |||||||
![]() Wisconsin 2-495% +26½ -110FanDuel | |||||||
Air Force 1-529% -3½ -115FanDuel | |||||||
UAB 2-425% +21½ -110Caesars | |||||||
![]() Arizona State 4-240% +9½ -110Caesars | |||||||
Florida 2-436% -8½ -113BetRivers | |||||||
![]() Louisiana 2-467% +4 -113BetRivers | |||||||
![]() #18Virginia 5-10% -17 -105Caesars | |||||||
Rutgers 3-3100% +17½ -115FanDuel | |||||||
![]() Georgia Southern 2-411% -6½ -110Bet365 | |||||||
![]() Colorado State 2-460% -2½ -110Bet365 | |||||||
UCLA 2-433% -3 -120SugarHouse | |||||||
Iowa 4-278% -2½ -118FanDuel | |||||||
Kentucky 2-369% +12½ -110Caesars | |||||||
![]() #19South Florida 5-10% -21½ -110Caesars | |||||||
Syracuse 3-329% +11 -112BetRivers | |||||||
#13Notre Dame 4-261% -9 -110Caesars | |||||||
#6Alabama 5-130% -7½ -118FanDuel | |||||||
Auburn 3-362% +2 -114BetRivers | |||||||
Oklahoma State 1-587% +22 -109BetRivers | |||||||
#15Brigham Young 6-058% +3½ -110BetMGM | |||||||
![]() New Mexico 3-30% -11½ -110Caesars | |||||||
![]() Oregon State 0-7- -20½ -110FanDuel | |||||||
Stanford 2-475% +18 -110Caesars | |||||||
![]() Liberty 3-430 -10½ -108Caesars | |||||||
![]() South Alabama 1-614 -7½ -115BetMGM | |||||||
![]() Western Kentucky 5-26 -10 -110Bet365 |
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