Live College Football Odds and Betting Lines for Oct 16-20

Compare the best college football odds and betting lines. With live odds updates from the top U.S. sportsbooks and data to help you make well-informed bets, OddsTrader is a must for college football bettors.

Compare Betting Lines with our CFB Odds Grid

Our grid system is designed to help you get the most value out of your college football bets. Simply scroll through the list of all this week’s games. Once you find a matchup you’d like to bet on, you can compare odds from the best sportsbooks to find the most favorable betting line.

You can choose between spread, moneyline, or over/under odds by clicking the dropdown menu above. There’s also the option to filter by full-game bets or choose a particular period (first half, second half, or any of the four quarters).

Looking for a specific game? You can narrow down your search by 10 different FBS conferences to streamline results. OddsTrader also has betting lines available for FCS, Division II, and Division III college football games.

Our grid constantly updates with the latest odds for every college football game. Before a game begins, we capture each sportsbook’s betting lines every 30 seconds. Once the game starts, that number increases to every 10 seconds. This ensures that our grid stays on top of the latest shifts with every play. 

Get In-depth College Football Data

On top of tracking live CFB lines and odds changes, our grid lets you take an in-depth look at every game. We provide key statistics and expert picks, plus vital information regarding relevant injuries and weather updates.

Bettors can find each team’s:

• Record against the spread
• Over/under splits
• Offensive and defensive stats
• Head-to-head history
• Recent results

Simply click on a specific game and scroll through the “Matchup” tab.

A wealth of information and the best college football odds are at your fingertips. You can make informed betting decisions while ensuring you get the most value out of your picks every single time.

Heisman Trophy and National Championship Odds

College football has two other popular betting markets beyond game matchups. They are futures bets that include Heisman Trophy winner and National Championship odds. 

The favorites to win the Heisman Trophy entering the season are:

• Texas quarterback Arch Manning (+800)
• Clemson quarterback Cade Klubnik (+900)
• LSU quarterback Garrett Nussmeier (+900)

The Texas Longhorns (+650) are the preseason favorites to win the 2025-26 National Championship. Right behind are the Ohio State Buckeyes (+700), Penn State Nittany Lions (+800), and Georgia Bulldogs (+900). 

Find the Best College Football Betting Sites and Promos

OddsTrader has partnered with the best sportsbooks in the business to bring you the most competitive odds for every NCAA football game. Check out the grid for our current rotation of sportsbooks, which includes Caesars, bet365, BetMGM, BetRivers, FanDuel, and DraftKings.

Read our hands-on breakdowns and learn everything you need to know about each of the best sportsbooks by clicking on our sportsbook review page. 

Win More with OddsTrader Turbo

Try a 30-day free trial of OddsTrader Turbo and unlock premium features to help elevate your betting game to the next level. By signing up, you’ll gain access to BetStation, our AI-enhanced college football betting hub.

With OddsTrader Turbo access, you’ll be able to ask important questions like:

• What are the best available CFB odds?
• What are today’s best underdog bets?
• How likely is Texas to cover the spread against Ohio State?
• Is the Alabama moneyline a valuable pick?

You’ll also gain access to our top-rated computer picks. Our five-star college football picks carry a win rate of 73% and are only available to OddsTrader Turbo subscribers.