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The upcoming matchup between the Clemson Tigers and the Pittsburgh Panthers is set to be an intriguing affair on November 16, 2024, at Acrisure Stadium, Pittsburgh, PA. The game will be broadcast live on ESPN at 12:00 PM. Clemson Tigers, the favorites, are coming off a robust season with a 7-2 straight-up record and a 5-4 against the spread (ATS) record, as shown on our NCAAF standings page. They have shown offensive prowess averaging 473.445 total yards per game, with standout performances from their starting quarterback. Meanwhile, Pittsburgh Panthers have a strong home record of 5-1, making them formidable opponents. Their recent form shows a mixed bag with a 7-2 straight-up record, but a consistent ATS performance of 6-3. In their last matchup on October 23, 2021, the Panthers triumphed over Clemson with a 27-17 score. The odds spread for this game is set at 11.5 points in favor of Clemson, with a total points line at 53, providing a thrilling betting opportunity. Both teams have strong stats, with Clemson's defense allowing just 336.667 total yards per game, while Pittsburgh's offense averages 427.778 total yards. This clash promises to be a showcase of strategic plays and key player performances.