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Mark your calendar for Saturday football on October 18, 2025, as the SMU Mustangs visit the Clemson Tigers at Memorial Stadium in Clemson, SC. The game airs on acc network and kicks off an exciting NCAAF showdown.
Our betting trends underline a key quarterback battle. Clemson’s starter has averaged 278.8 passing yards and 23.7 completions per game, while SMU’s quarterback sits at 277.8 yards and 23 completions. These game insights signal a potential shootout.
Clemson’s defense holds opponents to just 218.3 passing yards and 104.8 rushing yards per contest, while the Mustangs yield 315.8 through the air and 107.3 on the ground. Offensively, Clemson averages 278.8 pass yards and 130.0 rush yards per game, and SMU contributes 277.8 through the air and 127.0 on the ground.
The Tigers allow only 1.17 sacks per game compared to SMU’s 1.83 allowed, despite the Mustangs averaging 3.17 sacks themselves. Clemson’s 0-3 ATS mark at home is concerning, as seen on our NCAAF standings page, while SMU is 0-2 ATS on the road.
Clemson enters as a 9.5-point favorite (-110) with the total set at 55.5 (-110). With both defenses trending under and a slate of strategic matchups, the under 55.5 is my best bet at Caesars.
In their last meeting on December 7, 2024, the Tigers edged SMU 34-31. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
East Carolina 3-355% -16½ -114FanDuel | |||||||
![]() #2Miami (FL) 5-049% -13½ -110Caesars | |||||||
Minnesota 4-233% +7½ -102FanDuel | |||||||
![]() Utah State 3-335% -3 -120Caesars | |||||||
![]() California 4-246% -9½ -118BetRivers | |||||||
Miami (OH) 3-322% -12½ -115FanDuel | |||||||
![]() Boston College 1-568% -1½ -110Bet365 | |||||||
![]() Duke 4-277% -1 -115SugarHouse | |||||||
Bowling Green 3-336% -4 -118SugarHouse | |||||||
![]() #17Vanderbilt 5-152% -2½ -110Caesars | |||||||
![]() Michigan 4-258% -5½ -115BetMGM | |||||||
![]() Houston 5-148% +1½ -115BetMGM | |||||||
TCU 4-248% -2½ -122FanDuel | |||||||
![]() Tulane 5-130% -9½ -110Bet365 | |||||||
![]() South Carolina 3-369% +6 -117SugarHouse | |||||||
UCF 3-333% -7 -113BetRivers | |||||||
![]() Toledo 3-340% -26½ -110Caesars | |||||||
![]() Massachusetts 0-671% +17 -110Caesars | |||||||
![]() Louisiana-Monroe 3-370% +6 -110Caesars | |||||||
![]() Northwestern 4-245% -3 -113Caesars | |||||||
Appalachian State 4-20% -10 -110Bet365 | |||||||
![]() Ohio 3-30% -10½ -113BetRivers | |||||||
![]() James Madison 5-135% -1 -114BetRivers | |||||||
![]() Charlotte 1-556% +11½ -110Caesars | |||||||
![]() Clemson 3-344% -8½ -112BetRivers | |||||||
![]() #3Indiana 6-029% -27 -112BetRivers | |||||||
Marshall 3-365% +3 -115BetMGM | |||||||
Ball State 2-420% -1 -114BetRivers | |||||||
![]() Boise State 4-276% -12 -113BetRivers | |||||||
![]() North Texas 5-129% -3½ -115FanDuel | |||||||
![]() #9Georgia 5-162% -7½ -105BetMGM | |||||||
![]() Arkansas 2-481% +7½ -105FanDuel | |||||||
![]() Wisconsin 2-495% +26 -113BetRivers | |||||||
Air Force 1-520% -4 -112Caesars | |||||||
UAB 2-421% +21½ -110Caesars | |||||||
![]() Arizona State 4-236% +7½ -110Caesars | |||||||
Florida 2-443% -8½ -114SugarHouse | |||||||
![]() Louisiana 2-460% +3½ -108FanDuel | |||||||
![]() #18Virginia 5-114% -16½ -117SugarHouse | |||||||
Rutgers 3-381% +17½ -117BetRivers | |||||||
![]() Georgia Southern 2-48% -6½ -110Bet365 | |||||||
![]() Colorado State 2-457% -2½ -110Bet365 | |||||||
UCLA 2-437% -3 -120SugarHouse | |||||||
Iowa 4-281% -2½ -115FanDuel | |||||||
Kentucky 2-367% +12½ -105FanDuel | |||||||
![]() #19South Florida 5-114% -21½ -110Caesars | |||||||
Syracuse 3-340% +11½ -114SugarHouse | |||||||
#13Notre Dame 4-261% -9½ -105BetMGM | |||||||
#6Alabama 5-133% -8 -110Caesars | |||||||
Auburn 3-364% +2 -115SugarHouse | |||||||
Oklahoma State 1-585% +22½ -117SugarHouse | |||||||
#15Brigham Young 6-070% +4 -115BetRivers | |||||||
![]() New Mexico 3-320% -11½ -110Caesars | |||||||
![]() Oregon State 0-7- -22½ -110FanDuel | |||||||
Stanford 2-473% +18 -110Bet365 | |||||||
![]() Liberty 3-430 -10½ -108Caesars | |||||||
![]() South Alabama 1-614 -7½ -115BetMGM | |||||||
![]() Western Kentucky 5-26 -10 -110Bet365 | |||||||
![]() Jacksonville State 4-338 +3 -110Caesars | |||||||
![]() Sam Houston State 0-717 +3½ -114FanDuel |
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