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As the Iowa State Cyclones prepare to face the Colorado Buffaloes on October 11, 2025, at Folsom Field in Boulder, CO, sports bettors are gearing up for an exciting matchup. The Cyclones have demonstrated impressive form this season, boasting a 5-1 record, while the Buffaloes are struggling with a 2-4 record. This NCAAF clash promises intense action, with both teams aiming to capitalize on their strengths.
Quarterback play will be crucial in this game. The Cyclones' starting quarterback has been consistent, throwing for an average of 248.333 passing yards per game. The Buffaloes will need their defense to step up, as they've allowed an average of 218.833 passing yards per game. On the ground, the Cyclones have the edge, rushing for an average of 151 yards compared to the Buffaloes' 143.833.
Both teams have had mixed results against the spread, with the Buffaloes at 2-3-1 and the Cyclones at 3-2-1. The over/under trends also show variability, with Colorado going 2-4 and Iowa State 3-3. Given these stats, sports bettors should consider the Cyclones' strong away record and the Buffaloes' home advantage.
The game will be broadcast on ESPN, adding to the excitement of this Saturday football showdown. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
 Middle Tennessee 1-4- +2½ -105FanDuel | |||||||
 UTEP 1-4- +2½ -108FanDuel | |||||||
 Kennesaw State 3-2- +5½ -104FanDuel | |||||||
 Tulane 4-1- -7½ -102FanDuel | |||||||
 Sam Houston State 0-5- +10 -109BetRivers | |||||||
 Georgia Southern 2-3- -1½ -105FanDuel | |||||||
 North Texas 5-0- +1½ -115FanDuel | |||||||
 Colorado State 1-4- +5½ -110FanDuel | |||||||
 Washington 4-1- -9½ -115FanDuel | |||||||
 #18Florida State 3-2- -9½ -110FanDuel | |||||||
 Army 2-3- -14½ -110FanDuel | |||||||
 Michigan State 3-2- -4½ -115FanDuel | |||||||
 #19Missouri 5-0- +5½ -110FanDuel | |||||||
 Akron 2-4- - | |||||||
 Oklahoma State 1-4- +9½ -115FanDuel | |||||||
 #22Illinois 5-1- +15½ -105FanDuel | |||||||
 James Madison 4-1- - | |||||||
 Bowling Green 2-3- - | |||||||
 Cincinnati 4-1- -9½ -110FanDuel | |||||||
 SMU 3-2- -20½ -115FanDuel | |||||||
 #4Ole Miss 5-0- -33½ -115FanDuel | |||||||
 Eastern Michigan 1-5- - | |||||||
 Kent State 1-4- - | |||||||
 Western Michigan 3-3- - | |||||||
 Colorado 2-4- +4½ -110FanDuel | |||||||
 Maryland 4-1- +6½ -108FanDuel | |||||||
 #21Notre Dame 3-2- -22½ -110FanDuel | |||||||
 #7Penn State 3-2- -20½ -110FanDuel | |||||||
 #2Oregon 5-0- -9½ -115FanDuel | |||||||
 UNLV 5-0- - | |||||||
 #17Georgia Tech 5-0- -15½ -115FanDuel | |||||||
 #9Texas 3-2- -3½ -112FanDuel | |||||||
 Marshall 2-3- - | |||||||
 Oregon State 0-6- +6½ -115FanDuel | |||||||
 Georgia State 1-4- - | |||||||
 Kansas State 2-4- +1½ -118FanDuel | |||||||
 Temple 3-2- - | |||||||
 #15Tennessee 4-1- -12½ -112BetRivers | |||||||
 Florida Atlantic 2-3- - | |||||||
 Wyoming 2-3- - | |||||||
 Wisconsin 2-3- +3½ -122FanDuel | |||||||
 Coastal Carolina 2-3- - | |||||||
 #6Texas A&M 5-0- -7½ -115FanDuel | |||||||
 UTSA 2-3- - | |||||||
 Auburn 3-2- +6½ -110BetMGM | |||||||
 #11Texas Tech 5-0- -11½ -110FanDuel | |||||||
 USC 4-1- +1½ -110BetMGM | |||||||
 Boston College 1-4- +14½ -122FanDuel | |||||||
 Minnesota 3-2- -9½ -115FanDuel | |||||||
 #13LSU 4-1- -10½ -110FanDuel | |||||||
 Arizona 4-1- +1½ -105FanDuel | |||||||
 Texas State 3-2- - | |||||||
 Boise State 3-2- - | |||||||
 Utah 4-1- -4½ -112FanDuel | |||||||
 Nevada 1-4- - | |||||||
 Hawaii 4-2- -2½ -105FanDuel |
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