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The upcoming Saturday football showdown on December 6, 2025, features the Virginia Cavaliers hosting the Duke Blue Devils at the iconic Bank of America Stadium in Charlotte, NC. This highly anticipated NCAAF Week 15 matchup promises plenty of excitement and valuable betting trends for bettors looking to capitalize on game insights. Virginia, boasting a strong 10-2 straight-up record and impressive 8-4 ATS record, enjoys home-field advantage with a 6-1 SU and 5-2 ATS mark at home, making them favorites at a -4 point spread according to Caesars.
Virginia's defense allows just 203.4 passing yards per game and 108.9 rushing yards, while their offense averages 244.5 passing yards and 188.7 rushing yards, reflecting a balanced attack that can challenge Duke's defense. Duke, with a 7-5 SU record and 5-6-1 ATS, has shown offensive firepower, averaging 289.3 passing yards and 132.1 rushing yards per game, but their defense gives up 273.3 passing yards and 141 rushing yards. The Cavaliers' pass rush and solid pass protection could disrupt Duke's rhythm, influencing betting stats and trends.
Virginia's starting quarterback is expected to play without injury concerns, providing an edge over Duke's quarterback situation, which shows some inconsistency. The total points line is set at 57.5, with the over favored, reflecting expectations of a moderately high-scoring game. Bettors should consider these betting trends and game stats to make informed wagers. Don't miss the game broadcast on ABC, perfect for catching all the action live.
In their last matchup on November 15, 2025, Virginia defeated Duke 34-17, covering the spread comfortably. This recent result adds weight to Virginia's favored status and provides a historical betting reference. For those looking to dive deeper, our NCAAF standings page offers detailed ATS records and trends. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Jacksonville State 8-449% +2½ -108Caesars | |||||||
![]() #25James Madison 11-126% -23 -115SugarHouse | |||||||
#20Tulane 10-261% +2½ -102Caesars | |||||||
![]() Boise State 8-435% -3½ -120BetMGM | |||||||
![]() #4Texas Tech 11-129% -12½ -110Bet365 | |||||||
![]() Western Michigan 8-443% -1½ -110Bet365 | |||||||
#9Alabama 10-242% +2½ -105BetMGM | |||||||
![]() #17Virginia 10-222% -3½ -105BetMGM | |||||||
![]() #1Ohio State 12-049% -4 -110Bet365 |
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