Betting Trends Duke Blue Devils vs Virginia Cavaliers

The Saturday football clash on December 6, 2025, between the Duke Blue Devils and Virginia Cavaliers at Bank of America Stadium in Charlotte, NC, promises to be a thrilling NCAAF regular season matchup. Virginia enters as the favorite with a -3 point spread and a total points over/under set at 57.5, broadcasted on ABC. This game offers key betting trends to consider for savvy bettors.

Virginia Cavaliers have been strong at home with a 6-1 straight-up record and 5-2 ATS at home, showcasing a solid defense that limits opponents to an average of 312 rushing yards and 203 passing yards per game. Their offense averages 244 passing yards and 188 rushing yards, led by a starting quarterback who is expected to play despite a questionable status. Duke Blue Devils, on the other hand, have a 4-2 away record but a less impressive 3-2 ATS away. Their offense is slightly more pass-heavy with 289 passing yards per game but faces a tough Virginia pass rush averaging 2.5 sacks per game. Duke’s defense allows 273 passing yards and 141 rushing yards per game.

Key betting insights include Virginia’s strong pass defense against Duke’s pass offense and the Cavaliers' efficient run defense against Duke's run game. The Duke Blue Devils' offensive line will need to hold up against Virginia’s pass rush to protect their quarterback. The last matchup on November 15, 2025, saw Virginia defeat Duke 34-17, which could influence betting decisions this time around.

With the point spread at -3 favoring Virginia and an over/under of 57.5, bettors should consider Virginia’s home advantage and defensive strength. The best odds for Virginia at -3 are available at Caesars, and for Duke at +3, also at Caesars. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

Check out the detailed stats and records on our NCAAF standings page to make an informed wager.