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Get ready for a thrilling Saturday football showdown on October 4, 2025, as the Tennessee State Tigers take on the Eastern Illinois Panthers at O'Brien Field in Charleston, IL. This NCAAF matchup promises to be a captivating clash, with both teams eager to improve their standings. The Panthers, coming off a recent win against Western Illinois, are looking to capitalize on their home advantage. Eastern Illinois' pass offense, led by their starting quarterback, has been impressive, averaging 240.75 passing yards per game. However, they'll face a tough challenge against the Tigers' solid pass defense, which allows only 227.5 passing yards per game.
On the other side, the Tigers aim to bounce back from a narrow loss to Alabama A&M. Tennessee State's run offense has struggled, averaging only 106.75 rushing yards per game, and they'll need to find a way to break through the Panthers' defense, which has been effective in limiting opponents to 138 rushing yards on average. The key to this game could be the Panthers' ability to pressure the Tigers' quarterback, as Eastern Illinois' pass rush has been successful in generating sacks.
With the odds spread favoring Eastern Illinois by 2.5 points and a total points line set at 48.5, bettors should keep an eye on the Panthers' home record, which is 2-0 against the spread. Don't miss this exciting game on ESPN+ and consider placing your bets with a U.S. regulated sportsbook or Start your OddsTrader Turbo subscription for more insights and smarter bets.
![]() South Florida 3-113% -28 -110Caesars | |||||||
![]() Delaware 3-152% -2½ -115Caesars | |||||||
![]() San Jose State 1-355% -2½ -110Caesars | |||||||
#23Brigham Young 4-038% -18½ -118FanDuel | |||||||
San Diego State 3-129% -5½ -122FanDuel | |||||||
Navy 4-017% -12 -110Caesars | |||||||
![]() #12Georgia 3-128% -20½ -105FanDuel | |||||||
![]() Cincinnati 3-168% -1½ -110Caesars | |||||||
![]() #20Michigan 3-137% -17 -110Caesars | |||||||
![]() North Carolina 2-267% +14½ -105FanDuel | |||||||
![]() Pittsburgh 2-238% -6 -114SugarHouse | |||||||
Ball State 1-377% +14½ -108Caesars | |||||||
![]() Purdue 2-272% +9½ -104FanDuel | |||||||
Baylor 3-241% -6 -110Caesars | |||||||
UAB 2-237% +7½ -128FanDuel | |||||||
Temple 2-243% +6½ -106FanDuel | |||||||
Virginia Tech 2-341% -5½ -118BetMGM | |||||||
![]() North Carolina State 3-2- -42½ -110Bet365 | |||||||
![]() Massachusetts 0-485% +14 -118BetRivers | |||||||
![]() Arizona 3-127% -20½ -105FanDuel | |||||||
Appalachian State 2-227% -1½ -110Caesars | |||||||
Louisville 4-062% -6 -115BetRivers | |||||||
Maryland 4-042% +6½ -105FanDuel | |||||||
![]() Akron 1-465% +7½ -110Caesars | |||||||
Buffalo 2-325% -9½ -118BetMGM | |||||||
Georgia State 1-379% +20½ -115BetMGM | |||||||
![]() Northwestern 2-255% -11½ -110Bet365 | |||||||
![]() Northern Illinois 1-374% +5½ -114SugarHouse | |||||||
UCLA 0-473% +25 -114BetRivers | |||||||
Florida 1-366% +6 -115SugarHouse | |||||||
#10Alabama 3-142% -10½ -110Caesars | |||||||
SMU 2-252% -17½ -105BetMGM | |||||||
![]() Connecticut 3-236% -7 -110Caesars | |||||||
#21Notre Dame 2-227% -20½ -110Caesars | |||||||
Nebraska 3-160% -11 -115SugarHouse | |||||||
![]() #5Oklahoma 4-028% -45½ -109BetRivers | |||||||
Arkansas State 1-4100% +14 -115BetRivers | |||||||
![]() Old Dominion 3-129% -20 -113BetRivers | |||||||
Troy 2-222% +1½ -120FanDuel | |||||||
Rice 3-237% -4½ -110Caesars | |||||||
![]() Houston 4-080% +12 -114SugarHouse | |||||||
Wyoming 2-276% +3½ -110Caesars | |||||||
UCF 3-172% +5 -113BetRivers | |||||||
![]() #1Ohio State 4-06% -23½ -110Caesars | |||||||
#18Florida State 3-153% +4½ -110FanDuel | |||||||
TCU 3-130% -13½ -105Caesars | |||||||
#6Texas A&M 4-055% -14½ -115FanDuel | |||||||
![]() Memphis 5-011% -20 -113BetRivers | |||||||
![]() California 4-182% +3 -112BetRivers | |||||||
![]() Fresno State 4-140% -13½ -110Caesars | |||||||
New Mexico State 3-237 +2½ -115SugarHouse |
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