Betting Trends Indiana Hoosiers vs Ohio State Buckeyes

The highly anticipated Saturday football clash on December 6, 2025, features the Indiana Hoosiers vs Ohio State Buckeyes at Lucas Oil Stadium in Indianapolis, IN. This 2025-26 NCAAF regular season Week 15 showdown promises to deliver significant betting trends and game insights for bettors looking to capitalize on this prime matchup.

Ohio State, boasting a perfect 12-0 home record and a formidable 6-0 ATS record at home, is favored by 4 points with a total points line set at 47.5. Indiana, undefeated on the road with a 5-0 away record, will look to upset the Buckeyes in front of a home crowd. The starting quarterbacks for both teams are key to watch, with Ohio State’s offense averaging 267 passing yards and 171 rushing yards per game, while Indiana counters with a balanced attack of 254 passing yards and 230 rushing yards per game.

Defensively, Ohio State ranks impressively with only 121 passing yards allowed and 203 rushing yards allowed per game, which challenges Indiana's offensive output. Betting stats indicate Ohio State's strong pass protection against Indiana’s pass rush could be a decisive factor. The point spread of -4 for Ohio State reflects their edge but also presents value given Indiana’s recent dominant performances, including a 56-3 win over Purdue and a 31-7 victory against Wisconsin.

For bettors, the game insights suggest considering Ohio State's home dominance and defensive resilience while factoring in Indiana's high-scoring offense and undefeated away record. The TV broadcast on Fox ensures fans and bettors can catch all the action live. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

In their last matchup on November 23, 2024, Ohio State Buckeyes defeated Indiana Hoosiers 38-15, which provides useful betting trends to analyze for this upcoming game.