Betting Trends Indiana Hoosiers vs Ohio State Buckeyes

The upcoming Saturday football game on December 6, 2025, between the Indiana Hoosiers and Ohio State Buckeyes at Lucas Oil Stadium in Indianapolis, IN, promises an exciting clash in the 2025-26 NCAAF season. Indiana Hoosiers have been impressive recently, dominating their opponents with significant wins like 56-3 over Purdue and 55-10 against Maryland. Ohio State Buckeyes also boast a strong record with commanding victories such as 42-9 over Michigan and 48-10 against UCLA. Both teams have notable starting quarterbacks expected to play, contributing to a dynamic battle on the field.

Analyzing betting trends, Ohio State holds a clear advantage with a 10-1-1 ATS record, especially strong at home with a perfect 6-0 ATS. Indiana, while undefeated straight up on the road (5-0), has a more modest 3-2 ATS away record. The point spread is set at Ohio State -4, reflecting their favored status, while the total points line is 47.5, suggesting a moderately high-scoring game. Indiana's balanced offense, averaging 254 passing yards and 230 rushing yards per game, faces Ohio State's top-tier defense allowing just 121 passing yards and 203 rushing yards on average. Ohio State’s offense, led by a quarterback with 267 passing yards per game, will test Indiana’s defense that concedes 172 passing yards and 251 total yards.

The matchup also highlights contrasts in pass protection and pass rush, with Ohio State’s defensive line known for strong pressure potentially disrupting Indiana’s quarterback rhythm. Indiana’s offensive line will need to counter Ohio State’s aggressive pass rush to maintain their scoring momentum. This game is broadcasted on FOX, providing fans and bettors with live action to analyze and wager confidently.

In their last matchup on November 23, 2024, Ohio State Buckeyes defeated Indiana Hoosiers 38-15, a game that saw Ohio State cover the spread comfortably. Bettors can leverage this historical context alongside current season stats and betting trends to make educated wagers. The best odds available today for Indiana are +4 at Caesars and for Ohio State -4 at Caesars. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.