Indiana Hoosiers vs Ohio State Buckeyes Odds

The upcoming showdown on December 6, 2025, between the Indiana Hoosiers and Ohio State Buckeyes at Lucas Oil Stadium in Indianapolis, IN, is set to be a thrilling Saturday football event in the 2025-26 NCAAF season. Broadcast on FOX, this game offers an exciting opportunity for bettors to explore the latest odds and betting lines.

Currently, the Ohio State Buckeyes are favored with a point spread of -4 -109, while the Indiana Hoosiers are the underdogs at +4 -112, reflecting a slight shift from the opening line of a 4-point spread. This movement indicates some confidence in Ohio State's ability to cover the spread. The over/under is set at 47, with the under priced at -110, suggesting a potentially tight defensive game.

These betting odds provide valuable insights for bettors looking to make informed decisions. Understanding how the point spread and totals have shifted since opening lines can give bettors an edge in predicting the game's outcome. For those interested in more comprehensive betting options, the 2025-26 NCAAF odds page is a great resource.

Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit from the edge. The best odds available today for Indiana Hoosiers is +4 -112 at Caesars and for Ohio State Buckeyes -4 -109 at Caesars.