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The upcoming Friday football showdown on November 28, 2025, between the Purdue Boilermakers and Indiana Hoosiers at Ross-Ade Stadium in West Lafayette, IN, promises an intense clash in the 2025-26 NCAAF season. This game is broadcast on NBC, offering fans an exciting viewing opportunity. The starting quarterbacks for both teams are expected to play, with Indiana's squad showing a strong pass offense averaging 259.6 passing yards per game, while Purdue's defense counters with a solid pass defense allowing 246 passing yards. Indiana's run offense is robust, averaging 218 rushing yards, whereas Purdue's run defense allows 166 rushing yards per game, making the ground game a critical factor in betting trends for this matchup.
Betting insights reveal Indiana as the favorite with a -28.5 point spread and a total points line set at 53.5, favoring the under. Indiana boasts an impressive 11-0 straight-up record this season and a 6-5 ATS record, while Purdue struggles with a 2-9 straight-up record and 4-6-1 ATS. The last matchup on November 30, 2024, saw Indiana dominate Purdue 66-0, indicative of Indiana's strong home advantage and overall team strength. Key players from Indiana have consistently outperformed against Purdue, adding weight to the betting trends favoring Indiana.
Pass protection and pass rush dynamics will be crucial, with Indiana's offensive line providing solid protection to their quarterback, while Purdue's defense will try to disrupt. The game stats and betting trends suggest a strong lean towards Indiana, but bettors should consider Purdue's potential to cover the spread given their history of close games. For detailed analysis and the best odds, check out our OddsTrader Turbo subscription and place your bet with a U.S. regulated sportsbook to gain the edge.
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