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FINAL
Nov 29, 2025 12:00 PM EST
UK 0 vs LOU 41
Week 14
LOU
-1½ (+100)o45½ (-110)
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Kentucky Wildcats vs Louisville Cardinals Odds
Updated:Nov 29, 2025 1:50 AM EST
The highly anticipated NCAAF showdown between the Louisville Cardinals and the Kentucky Wildcats is set for November 29, 2025, at L&N Federal Credit Union Stadium in Louisville, KY. This Saturday football game promises to be a thrilling contest as these two rivals battle it out in the 2025-26 season. Fans can catch all the action live on ESPN Networks and the ACC Network, making it a can't-miss event.
When it comes to betting, the odds currently favor the Louisville Cardinals as the favorite with a point spread of -2½ -114, while the Kentucky Wildcats are the underdogs at +2½ -106. These betting lines have shifted slightly since opening, indicating some movement in favor of Louisville, which bettors should consider when placing their wagers. The total points line is set at 46½, with the over at -114 and the under at -106, providing additional opportunities for strategic betting.
Understanding these odds and betting lines is crucial for making informed bets. The Louisville Cardinals' home advantage at L&N Federal Credit Union Stadium could play a significant role, but Kentucky's resilience makes this an intriguing matchup. For those looking to dive deeper into the NCAAF betting landscape, our comprehensive NCAAF odds page offers valuable insights and updated lines.
Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. The best odds available today for Louisville is - at Caesars and for Kentucky - at Caesars.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
KentuckySpread
-1.0%
EV
-1.0%
LouisvilleSpread
-4.4%
EV
-4.4%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
KentuckyMONEYLINE
+0.2%
EV
+0.2%
LouisvilleMONEYLINE
-3.4%
EV
-3.4%
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Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
+2.7%
EV
+2.7%
UNDERTotal
-9.6%
EV
-9.6%
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LouisvilleMONEYLINE
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KentuckyMONEYLINE
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