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The upcoming Saturday football game on November 22, 2025, between the Vanderbilt Commodores and Kentucky Wildcats at FirstBank Stadium in Nashville, TN, promises an exciting SEC showdown in the 2025-26 NCAAF season. Vanderbilt enters this matchup with a strong home record of 6-0 and an impressive ATS record of 5-1 at home, making them a formidable opponent. Kentucky, with a 1-2 away record and a 5-5 ATS overall, looks to challenge the Commodores on their turf.
Both teams showcase contrasting strengths that will influence betting trends. Vanderbilt's offensive game is robust, averaging 258.4 passing yards and 185.2 rushing yards per game, while Kentucky's defense allows 215.8 passing yards and 128.8 rushing yards. Kentucky counters with a solid offense averaging 203.9 passing yards and 159.9 rushing yards, facing Vanderbilt's defense which permits 244.7 passing yards but a stingier 112.5 rushing yards. This dynamic sets up a tactical battle between pass offense versus pass defense and run offense versus run defense.
Quarterback analysis shows Vanderbilt likely to start their primary QB, who has been effective leading the offense, while Kentucky's starter has shown resilience despite some injury concerns. Vanderbilt's pass protection has faced challenges against strong pass rushes, whereas Kentucky's offensive line has maintained better protection. The point spread currently favors Vanderbilt at -9.5 with a total points over/under set at 53.5, indicating a moderately high-scoring game expected by sportsbooks like Caesars.
Recent form favors Vanderbilt, with notable wins including a 38-45 victory over Auburn and a 31-34 close loss at Texas, while Kentucky has dominated teams like Tennessee Tech and Florida but suffered recent losses to Tennessee Volunteers and Texas Longhorns. These game stats and betting insights provide valuable data for making informed wagers.
For those looking to capitalize on the best betting trends for this matchup, consider the strengths of Vanderbilt at home and the offensive-defensive matchups. The game will be broadcast on ESPN, providing fans with comprehensive coverage. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Don't miss the detailed analysis of their last matchup on October 12, 2024 where Vanderbilt edged Kentucky 20-13.
![]() Ohio 6-423% -33 -110Bet365 | |||||||
Bowling Green 3-748% -2½ -118FanDuel | |||||||
![]() Northern Illinois 3-757% +7 -117BetRivers | |||||||
Buffalo 5-550% +1½ -110Bet365 | |||||||
![]() Kent State 4-681% +9½ -105Bet365 | |||||||
Arkansas State 5-50% -2½ -117Caesars | |||||||
![]() North Carolina State 5-564% +5 -118BetRivers | |||||||
UNLV 8-211% -2½ -110FanDuel | |||||||
![]() #1Ohio State 10-040% -30½ -114FanDuel | |||||||
Army 5-450% -9½ -120FanDuel | |||||||
![]() Wake Forest 7-318% -17 -109BetRivers | |||||||
Virginia Tech 3-775% +18 -117SugarHouse | |||||||
![]() #11Oklahoma 8-236% -7½ -105BetMGM | |||||||
SMU 7-313% -2½ -124FanDuel | |||||||
![]() Iowa State 6-40% -4 -114BetRivers | |||||||
![]() Northwestern 5-50% -3½ -110Bet365 | |||||||
#3Texas A&M 10-0- - | |||||||
![]() #5Georgia 9-155% -43½ -115FanDuel | |||||||
![]() Georgia Southern 5-567% +12½ -110Bet365 | |||||||
![]() James Madison 9-122% -12½ -115FanDuel | |||||||
![]() Arizona 7-314% -6½ -110Bet365 | |||||||
![]() Toledo 6-450% -27 -110BetRivers | |||||||
Wyoming 4-60% -6½ -110Bet365 | |||||||
![]() Kennesaw State 7-317% -6½ -105FanDuel | |||||||
#4Alabama 8-2- - | |||||||
Auburn 4-6- - | |||||||
Appalachian State 4-686% +4½ -109Caesars | |||||||
![]() Florida Atlantic 4-683% +7½ -115BetMGM | |||||||
![]() UTEP 2-840% -3 -110Bet365 | |||||||
![]() Middle Tennessee 1-917% -6½ -115BetMGM | |||||||
![]() Louisiana Tech 5-50% +1½ -118FanDuel | |||||||
UAB 3-775% +21½ -109Caesars | |||||||
![]() North Carolina 4-689% +7 -114BetRivers | |||||||
![]() #10Texas 7-310% -8½ -110FanDuel | |||||||
![]() #8Oregon 9-141% -9½ -115BetMGM | |||||||
#21Iowa 6-422% -16½ -110Bet365 | |||||||
![]() UTSA 5-5100% +2½ -105BetMGM | |||||||
![]() #14Vanderbilt 8-218% -8½ -118SugarHouse | |||||||
![]() South Alabama 3-7100% +2½ -110FanDuel | |||||||
![]() Florida International 5-50% +1½ -120BetMGM | |||||||
#9Notre Dame 8-233% -35 -110Bet365 | |||||||
Temple 5-587% +8½ -113BetRivers | |||||||
UCF 4-640% -14 -105BetMGM | |||||||
Maryland 4-6100% +13½ -105BetMGM | |||||||
![]() Houston 8-20% -1 -114BetRivers | |||||||
![]() #13Utah 8-210% -17 -120Bet365 | |||||||
Troy 6-433% -11 -110Bet365 | |||||||
![]() South Carolina 3-725% -23½ -110FanDuel | |||||||
![]() Clemson 5-5- - | |||||||
Texas State 4-6- -17½ -110Bet365 | |||||||
![]() #16Georgia Tech 9-16% -2½ -110Bet365 | |||||||
![]() Penn State 4-625% -9½ -110Caesars | |||||||
![]() Boise State 6-40% -16½ -110Bet365 | |||||||
Air Force 3-7100% +3½ -114Caesars | |||||||
Florida 3-782% +5 -120BetRivers | |||||||
Stanford 3-791% +3 -109Caesars | |||||||
![]() Wisconsin 3-7100% +8½ -105FanDuel | |||||||
Rice 5-560% +18½ -110Bet365 | |||||||
LSU 6-433% -21½ -110Bet365 | |||||||
![]() #25Cincinnati 7-395% +2½ -106FanDuel | |||||||
![]() Colorado 3-789% +7½ -115Bet365 | |||||||
UCLA 3-775% +10½ -108Caesars | |||||||
San Diego State 8-20% -11½ -110BetMGM | |||||||
![]() Fresno State 7-30% -2½ -114BetRivers |
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