Nov 22, 2025 12:00 PM EST

Week 13

7-3

Louisville

7-3

SMU

-2½ (-110)

ESPN2, 209

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Betting Trends Louisville Cardinals vs SMU Mustangs

Updated:Nov 21, 2025 2:17 AM EST

The upcoming Saturday football game on November 22, 2025, between the Louisville Cardinals and SMU Mustangs at Gerald J. Ford Stadium in Dallas, TX, is set to be an exciting NCAAF matchup. This game, broadcast on ESPN2, offers plenty of betting trends and game insights to consider before placing your wager.

Louisville enters the game with a 7-3 straight-up record and a perfect 3-0 away record, though their ATS record stands at 3-7. The Cardinals have been competitive in recent games, including a narrow 20-19 loss to Clemson and a close 29-26 loss to California. SMU, the home team, holds a 7-3 straight-up record as well and has a strong 4-1 home record, but their ATS is 4-6 overall and 2-3 at home. The Mustangs have demonstrated strong offensive performances, including a 45-13 win over Boston College and a tight 26-20 victory over Miami (FL).

When looking at betting trends, Louisville's passing offense averages 243.3 yards per game, while SMU's passing defense allows 298.6 yards, indicating a potential advantage for Louisville's aerial attack. On the ground, Louisville rushes for 156.5 yards per game against SMU's run defense that allows 102.1 yards, which could favor Louisville's run game. SMU's offense, however, is potent with 284.5 passing yards and 122.1 rushing yards per game, facing a Louisville defense that allows 188 passing yards and 109.9 rushing yards, setting up an intriguing clash of offensive and defensive strengths.

Louisville's starting quarterback is expected to lead the offense, while SMU's quarterback, likely the starter barring injury, will test the Cardinals' pass rush. The point spread currently favors SMU by 2.5 points, with a total points over/under of 51.5, suggesting a moderately high-scoring game. Bettors should consider these betting stats and trends to make informed decisions. The Cardinals' strong away performance and SMU's home advantage create a balanced betting landscape.

For those looking to dive deeper into the numbers, the last matchup on October 5, 2024, where SMU edged Louisville 34-27 offers valuable context. The Cardinals and Mustangs are both competitive teams with solid records, and the NCAAF standings page provides insight into their ATS performances this season.

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Who is favored in the Louisville Cardinals vs SMU Mustangs game?

ATS Records

Louisville

SMU

All

All
1st half
2nd half
1st quarter
2nd quarter
3rd quarter
4th quarter

3-7 (239th)Against the Spread4-6 (187th)

7-3 (68th)Straight Up7-3 (75th)

+1.4Straight Up Units+1.5

5-5Over / Under3-7

TEAM MATCHUP

Louisville

SMU

OFF

DEF

OFF

DEF

31.5Points32.2

399.8Total Yards406.6

6Yards Per Play6

243.3Passing Yards284.5

22.6 - 35.3 (64%)Completions-Attempts23 - 35.4 (65%)

6.9Yards Per Passing Play8

14.4Sacks-Yards Lost15.5

156.5Rushing Yards122.1

30.6Attempts30.2

5.1Yards Per Rush4

19.71st Downs20

10.4Passing11.1

7.6Rushing6.9

1.7Penalties2

5.1 / 13.4 (38.1%)3rd Down5 / 13.5 (37%)

0.4 / 0.9 (44.4%)4th Down0.6 / 1 (60%)

2.7 / 3 (90%)Red Zone2.8 / 3.2 (87.5%)

6.9 (65.2)Penalties (Yards)6.9 (71.2)

0.8Interceptions0.9

0.7Fumbles Lost0.6

67.8Total Plays67.2

6.5Kickoffs6.3

1.3Returns1.1

30.5Yards22.2

23.5Yards Per Return20.2

4.3Punts4.6

2.1Returns1.5

43.1Yards14.9

20.5Yards Per Return9.9

HEAD TO HEAD

Louisville

LOU

SMU

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

Game

Game
1H
2H
1Q
2Q
3Q
4Q

This Week

Last Week

NCAAF Fri 11/21

Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/218:00 PM Florida State 5-5 56% -5½ -110BetMGM
North Carolina State 5-5 44% +6 -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/2110:30 PM Hawaii 7-3 59% +3 -110Bet365
UNLV 8-2 41% -2 -129SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Rutgers 5-5 70% +32½ -110BetRivers
#1Ohio State 10-0 30% -31½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Tulsa 3-7 64% +10 -105BetMGM
Army 5-4 36% -9½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Delaware 5-5 70% +17½ -108FanDuel
Wake Forest 7-3 30% -17½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #13Miami (FL) 8-2 38% -17½ -110Bet365
Virginia Tech 3-7 62% +18½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #22Missouri 7-3 66% +7 -110BetMGM
#8Oklahoma 8-2 34% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Louisville 7-3 76% +3 -113Caesars
SMU 7-3 24% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Kansas 5-5 65% +3½ -105BetMGM
Iowa State 6-4 35% -3½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Minnesota 6-4 61% +4 -118BetRivers
Northwestern 5-5 39% -3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Samford 1-10 - +55½ -110FanDuel
#3Texas A&M 10-0 - -54½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:45 PM Charlotte 1-9 52% +44 -114BetRivers
#4Georgia 9-1 48% -43½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Old Dominion 7-3 44% -10½ -110Bet365
Georgia Southern 5-5 56% +12½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Washington State 5-5 69% +14 -113BetRivers
James Madison 9-1 31% -13½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Baylor 5-5 70% +7 -114Caesars
Arizona 7-3 30% -6½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Ball State 4-6 13% +28½ -122FanDuel
Toledo 6-4 87% -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Nevada 2-8 90% +7½ -120FanDuel
Wyoming 4-6 10% -6½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Missouri State 7-3 78% +6½ -110BetMGM
Kennesaw State 7-3 22% -6½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Mercer 9-1 - +27½ -110Bet365
Auburn 4-6 - -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Eastern Illinois 3-8 - +50½ -110FanDuel
#10Alabama 8-2 - -50½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:30 PM Marshall 5-5 36% -4½ -114BetRivers
Appalachian State 4-6 64% +5½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Connecticut 8-3 12% -7 -110Caesars
Florida Atlantic 4-6 88% +7½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM New Mexico State 3-7 75% +3½ -117BetRivers
UTEP 2-8 25% -3 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Sam Houston State 2-8 60% +6½ -104Caesars
Middle Tennessee 1-9 40% -6½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Liberty 4-6 70% +1½ -125BetMGM
Louisiana Tech 5-5 30% +1½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM South Florida 7-3 28% -21½ -108FanDuel
UAB 3-7 72% +21½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Duke 5-5 18% -6½ -120FanDuel
North Carolina 4-6 82% +7 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Arkansas 2-8 85% +9 -110Bet365
#17Texas 7-3 15% -8½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM #15USC 8-2 54% +10 -110Bet365
#7Oregon 9-1 46% -9½ -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Michigan State 3-7 71% +17 -110Caesars
Iowa 6-4 29% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM East Carolina 7-3 19% -2½ -110Bet365
UTSA 5-5 81% +2½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Kentucky 5-5 89% +9½ -110Bet365
#14Vanderbilt 8-2 11% -8½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Southern Miss 7-3 46% -1½ -107Caesars
South Alabama 3-7 54% +2½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Jacksonville State 7-3 14% +½ -110SugarHouse
Florida International 5-5 86% +1½ -120Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Syracuse 3-7 33% +36 -110Caesars
#9Notre Dame 8-2 67% -35 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:45 PM #24Tulane 8-2 22% -7½ -115FanDuel
Temple 5-5 78% +9½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Oklahoma State 1-9 77% +14 -110Bet365
UCF 4-6 23% -13 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM #18Michigan 8-2 27% -13½ -120FanDuel
Maryland 4-6 73% +14 -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM TCU 6-4 57% +2 -110Bet365
#23Houston 8-2 43% -1 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Kansas State 5-5 74% +17½ -110BetMGM
#12Utah 8-2 26% -17 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Georgia State 1-9 57% +10½ -110Bet365
Troy 6-4 43% -10 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:15 PM Coastal Carolina 6-4 70% +24 -108Caesars
South Carolina 3-7 30% -23½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:30 PM Furman 6-5 - +41½ -110FanDuel
Clemson 5-5 - -41½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/225:00 PM Louisiana-Monroe 3-7 33% +19½ -110Bet365
Texas State 4-6 67% -18 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Pittsburgh 7-3 92% +3 -117BetRivers
#16Georgia Tech 9-1 8% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Nebraska 7-3 63% +9½ -104FanDuel
Penn State 4-6 37% -8 -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Colorado State 2-8 100% +17½ -115BetMGM
Boise State 6-4 0% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM New Mexico 7-3 8% -3½ -102FanDuel
Air Force 3-7 92% +4 -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #20Tennessee 7-3 19% -3½ -118FanDuel
Florida 3-7 81% +4½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM California 6-4 17% -2½ -120FanDuel
Stanford 3-7 83% +3½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #21Illinois 7-3 12% -8 -114BetRivers
Wisconsin 3-7 88% +8½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM North Texas 9-1 20% -17½ -115BetMGM
Rice 5-5 80% +18½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:45 PM Western Kentucky 8-2 69% +22 -112Caesars
LSU 6-4 31% -21½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #11Brigham Young 9-1 14% -2 -110Bet365
Cincinnati 7-3 86% +2½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #25Arizona State 7-3 13% -7 -110Caesars
Colorado 3-7 87% +7½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Washington 7-3 15% -10½ -109Caesars
UCLA 3-7 85% +10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM San Jose State 3-7 88% +12½ -110BetMGM
San Diego State 8-2 12% -12 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Utah State 5-5 100% +3 -113BetRivers
Fresno State 7-3 0% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Massachusetts 0-11 14 +34½ -115BetMGM
Ohio 7-4 42 -33½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Akron 5-7 19 +3 -114BetRivers
Bowling Green 3-8 16 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Western Michigan 7-4 35 -6 -115Bet365
Northern Illinois 3-8 19 +7½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Miami (OH) 6-5 37 -1½ -120BetMGM
Buffalo 5-6 20 +2½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Central Michigan 7-4 28 -7½ -110Bet365
Kent State 4-7 16 +8½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/207:30 PM Louisiana 5-6 34 +3 -120BetRivers
Arkansas State 5-6 30 -2½ -110Bet365

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Betting Trends Louisville Cardinals vs SMU Mustangs

ATS Records

Louisville

SMU

TEAM MATCHUP

Louisville

SMU

Recent Results

Louisville

SMU

HEAD TO HEAD

Louisville

SMU

Louisville

UPCOMING SCHEDULE

SMU