Louisville Cardinals vs SMU Mustangs Injury Report

The upcoming Saturday football game on November 22, 2025, between the Louisville Cardinals and SMU Mustangs in the NCAAF promises to be a thrilling matchup at Gerald J. Ford Stadium in Dallas, TX. Fans and bettors alike should pay close attention to the detailed injury report as it can significantly impact the game's outcome and betting strategies.

Louisville Cardinals face notable challenges with several key players injured. Running Backs Isaac Brown and Keyjuan Brown are both out due to lower leg and undisclosed injuries, respectively, expected to return by November 29, 2025. Tight End Jacob Stewart is probable, while Quarterback Miller Moss is questionable, both with undisclosed injuries. Linebacker TJ Quinn is probable, but several others including RB Shammai Gates and LB Antonio Watts are out. These key injuries could affect the Cardinals' offensive and defensive capabilities significantly.

The SMU Mustangs are also dealing with significant injuries. Defensive End Aakil Washington and Defensive Tackle Jonathan Jefferson are out, as are Cornerback La'Modrick Spencer and Wide Receiver Isaiah Robertson. Defensive End Cameron Robertson is questionable, and Offensive Lineman PJ Williams is probable. These injuries could influence SMU's defensive and offensive line strength in the game.

Understanding these player injuries is crucial for making informed betting decisions. For more detailed player status updates, visit the NCAAF injury list. The game will be broadcast on ESPN2, providing fans with live coverage. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.