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FINAL
Nov 22, 2025 12:00 PM EST
LOU 6 vs SMU 38
Week 13
SMU
-3½ (-110)o49½ (-110)
ESPN2, 209BETCAST
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Louisville Cardinals vs SMU Mustangs Odds
Updated:Nov 22, 2025 2:01 AM EST
The upcoming matchup on November 22, 2025, features the Louisville Cardinals taking on the SMU Mustangs at Gerald J. Ford Stadium in Dallas, TX. This Saturday football game in the NCAAF promises excitement as both teams vie for a crucial win in Week 13 of the regular season. Fans can catch the action live on ESPN2, making it a prime opportunity to follow the latest odds and betting lines.
Currently, the SMU Mustangs are favored with a point spread of -4 -111, while the Louisville Cardinals hold +4 -110 on the spread. The over under is set at 50 -110, indicating a balanced expectation for scoring. Opening odds saw a similar spread, but the slight movement in the point spread odds suggests bettor confidence leaning towards SMU. Understanding these odds and betting lines can help bettors make informed decisions to maximize their chances of winning.
For those interested in deeper analysis, the NCAAF odds page offers comprehensive insights into all games this season. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
LouisvilleSpread
-4.6%
EV
-4.6%
SMUSpread
+0.4%
EV
+0.4%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
LouisvilleMONEYLINE
-2.4%
EV
-2.4%
SMUMONEYLINE
-1.1%
EV
-1.1%
EXCLUSIVE BOOSTS
SMU, Kansas, South Florida & Duke All WinSMU to win; Kansas to win; South Florida to win; Duke to win
Missouri, Louisville & Iowa State All WinMissouri to win; Louisville to win; Iowa State to win
Boosts Available
Boosts are special bets with increased odds offered by sportsbooks for a limited time.
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
+4.4%
EV
+4.4%
UNDERTotal
-8.6%
EV
-8.6%
Spread (1H)
BEST LINE
LouisvilleSpread
SMUSpread
MONEYLINE (1H)
BEST LINE
LouisvilleMONEYLINE
SMUMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
MONEYLINE (2H)
BEST LINE
LouisvilleMONEYLINE
SMUMONEYLINE
Spread (1Q)
BEST LINE
LouisvilleSpread
SMUSpread
MONEYLINE (1Q)
BEST LINE
LouisvilleMONEYLINE
SMUMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
LouisvilleSpread
SMUSpread
MONEYLINE (2Q)
BEST LINE
LouisvilleMONEYLINE
SMUMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
LouisvilleSpread
SMUSpread
MONEYLINE (3Q)
BEST LINE
LouisvilleMONEYLINE
SMUMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
LouisvilleSpread
SMUSpread
MONEYLINE (4Q)
BEST LINE
LouisvilleMONEYLINE
SMUMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
NCAAF
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NCAAF Week 14
NCAAF Tue 11/25
 Massachusetts 0-11- - | |||||||
 Eastern Michigan 4-7- - | |||||||
 Memphis 8-3- -5½ -112FanDuel | |||||||
 Mississippi State 5-6- +9½ -113BetRivers | |||||||
 Nebraska 7-4- +5½ -105FanDuel | |||||||
 Kansas 5-6- +13½ -110FanDuel | |||||||
 Northern Illinois 3-8- - | |||||||
 Buffalo 5-6- - | |||||||
 Colorado State 2-9- - | |||||||
 #16Georgia Tech 9-2- +13½ -110FanDuel | |||||||
 New Mexico 8-3- +1½ -105FanDuel | |||||||
 North Texas 10-1- -18½ -110FanDuel | |||||||
 Utah State 6-5- - | |||||||
 #17Texas 8-3- +3½ -122FanDuel | |||||||
 Purdue 2-9- +28½ -110FanDuel | |||||||
 #25Arizona State 8-3- +1½ -112FanDuel | |||||||
 Florida Atlantic 4-7- +5½ -106FanDuel | |||||||
 Louisville 7-4- -3½ -105FanDuel | |||||||
 South Carolina 3-7- -2½ -110FanDuel | |||||||
 #18Michigan 9-2- +12½ -110Bet365 | |||||||
 Oklahoma State 1-10- +15½ -110FanDuel | |||||||
 Central Michigan 7-4- - | |||||||
 Miami (OH) 6-5- - | |||||||
 West Virginia 4-7- +21½ -122FanDuel | |||||||
 Duke 6-5- -3½ -105FanDuel | |||||||
 Pittsburgh 8-3- +6½ -105FanDuel | |||||||
 #19Virginia 9-2- -11½ -105FanDuel | |||||||
 Kansas State 5-6- -18½ -110FanDuel | |||||||
 TCU 6-4- -4½ -112FanDuel | |||||||
 Baylor 5-6- -1½ -114FanDuel | |||||||
 #11Brigham Young 10-1- -16½ -115FanDuel | |||||||
 California 6-5- +10½ -110FanDuel | |||||||
 Delaware 5-6- - | |||||||
 Sam Houston State 2-9- - | |||||||
 Marshall 5-6- - | |||||||
 Old Dominion 8-3- - | |||||||
 Jacksonville State 7-4- - | |||||||
 Missouri State 7-4- - | |||||||
 Appalachian State 5-6- - | |||||||
 Syracuse 3-8- +3½ -115FanDuel | |||||||
 Tulsa 4-7- -7½ -115FanDuel | |||||||
 Texas State 5-6- - | |||||||
 New Mexico State 4-7- - | |||||||
 Louisiana 5-6- - | |||||||
 #20Tennessee 8-3- -3½ -102FanDuel | |||||||
 Rutgers 5-6- +10½ -105FanDuel | |||||||
 #8Oklahoma 9-2- -10½ +100FanDuel | |||||||
 UTSA 6-5- -6½ -110FanDuel | |||||||
 Southern Miss 7-4- -6½ -108FanDuel | |||||||
 Arkansas 2-9- +2½ -110FanDuel | |||||||
 Minnesota 6-5- -2½ -110FanDuel | |||||||
 Washington 8-3- +6½ +102FanDuel | |||||||
 Liberty 4-7- - | |||||||
 Coastal Carolina 6-5- +21½ -115FanDuel | |||||||
 Florida 3-8- -4½ -102FanDuel | |||||||
 Washington State 5-6- - | |||||||
 South Florida 8-3- -23½ -115FanDuel | |||||||
 Michigan State 3-8- -4½ -110FanDuel | |||||||
 North Carolina State 6-5- -7½ -115FanDuel | |||||||
 Auburn 5-6- +6½ -113BetRivers | |||||||
 #24Tulane 9-2- -28½ -105FanDuel | |||||||
 #21Illinois 7-4- -6½ -122FanDuel | |||||||
 #15USC 8-2- -17½ -110FanDuel | |||||||
 Nevada 3-8- - | |||||||
 San Jose State 3-8- -2½ -105FanDuel | |||||||
 Stanford 4-7- +33½ -115FanDuel | |||||||
 Hawaii 7-4- - |
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