Nov 22, 2025 12:00 PM EST

Week 13

Louisville

7-3

SMU

-2½ (-110)

ESPN2, 209

MATCHUP PREDICTION ODDS BOOSTS PLAYER PROPS GAME PROPS INJURIES WEATHER

Event NotificationsStay on top of the action with alerts for game start, scoring, odds updates, predictions and more.

Don't show me this again

Louisville Cardinals vs SMU Mustangs Odds

Updated:Nov 21, 2025 1:20 AM EST

The upcoming Saturday football game on November 22, 2025, features the Louisville Cardinals visiting the SMU Mustangs at Gerald J. Ford Stadium in Dallas, TX. This exciting NCAAF regular season Week 13 matchup promises intense competition as both teams look to secure a crucial win. The game will be broadcast on ESPN2, making it accessible for fans and bettors nationwide.

Current odds favor the SMU Mustangs as the favorite with a point spread of -2½ at -114 odds, while the Louisville Cardinals are the underdog at +2½ with -106 odds. The total over/under is set at 51½, with the over at -112 and the under at -108. Opening odds had the SMU Mustangs at -2½ -110 and Louisville at +2½ -110, showing a slight shift in money movement that bettors should consider when placing their wagers.

Understanding these betting lines and odds is essential for making an informed betting decision. The Mustangs' home advantage at Gerald J. Ford Stadium could play a significant role, and the odds movement suggests some confidence in SMU's ability to cover the spread. For those interested in exploring more odds and betting options, visiting the NCAAF odds page can provide valuable insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

What is the point spread for the Louisville Cardinals vs SMU Mustangs game?

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

Game

Game
1H
2H
1Q
2Q
3Q
4Q

This Week

Last Week

NCAAF Fri 11/21

Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/218:00 PM Florida State 5-5 56% -5½ -110BetMGM
North Carolina State 5-5 44% +6 -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/2110:30 PM Hawaii 7-3 60% +3 -110Bet365
UNLV 8-2 40% -2 -129SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Rutgers 5-5 70% +32½ -110BetRivers
#1Ohio State 10-0 30% -31½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Tulsa 3-7 64% +10 -105BetMGM
Army 5-4 36% -9½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Delaware 5-5 70% +17½ -108FanDuel
Wake Forest 7-3 30% -17½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #13Miami (FL) 8-2 38% -17½ -110Bet365
Virginia Tech 3-7 62% +18½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #22Missouri 7-3 66% +7 -110BetMGM
#8Oklahoma 8-2 34% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Louisville 7-3 76% +3 -113Caesars
SMU 7-3 24% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Kansas 5-5 65% +3½ -105BetMGM
Iowa State 6-4 35% -3½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Minnesota 6-4 61% +4 -118BetRivers
Northwestern 5-5 39% -3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Samford 1-10 - +55½ -110FanDuel
#3Texas A&M 10-0 - -54½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:45 PM Charlotte 1-9 52% +44 -114BetRivers
#4Georgia 9-1 48% -43½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Old Dominion 7-3 44% -10½ -110Bet365
Georgia Southern 5-5 56% +12½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Washington State 5-5 69% +14 -113BetRivers
James Madison 9-1 31% -13½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Baylor 5-5 70% +7 -114Caesars
Arizona 7-3 30% -6½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Ball State 4-6 13% +28½ -122FanDuel
Toledo 6-4 87% -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Nevada 2-8 90% +7½ -120FanDuel
Wyoming 4-6 10% -6½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Missouri State 7-3 76% +6½ -110BetMGM
Kennesaw State 7-3 24% -6½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Mercer 9-1 - +27½ -110Bet365
Auburn 4-6 - -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Eastern Illinois 3-8 - +50½ -110FanDuel
#10Alabama 8-2 - -50½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:30 PM Marshall 5-5 36% -4½ -114BetRivers
Appalachian State 4-6 64% +5½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Connecticut 8-3 12% -7 -110Caesars
Florida Atlantic 4-6 88% +7½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM New Mexico State 3-7 75% +3½ -117BetRivers
UTEP 2-8 25% -3 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Sam Houston State 2-8 60% +6½ -104Caesars
Middle Tennessee 1-9 40% -6½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Liberty 4-6 70% +1½ -125BetMGM
Louisiana Tech 5-5 30% +1½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM South Florida 7-3 29% -21½ -108FanDuel
UAB 3-7 71% +21½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Duke 5-5 18% -6½ -120FanDuel
North Carolina 4-6 82% +7 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Arkansas 2-8 88% +9 -110Bet365
#17Texas 7-3 12% -8½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM #15USC 8-2 53% +10 -110Bet365
#7Oregon 9-1 47% -9½ -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Michigan State 3-7 71% +17 -110Caesars
Iowa 6-4 29% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM East Carolina 7-3 15% -2½ -110Bet365
UTSA 5-5 85% +2½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Kentucky 5-5 90% +9½ -110Bet365
#14Vanderbilt 8-2 10% -8½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Southern Miss 7-3 46% -1½ -107Caesars
South Alabama 3-7 54% +2½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Jacksonville State 7-3 14% +½ -110SugarHouse
Florida International 5-5 86% +1½ -120Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Syracuse 3-7 35% +36 -110Caesars
#9Notre Dame 8-2 65% -35 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:45 PM #24Tulane 8-2 23% -7½ -115FanDuel
Temple 5-5 77% +9½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Oklahoma State 1-9 77% +14 -110Bet365
UCF 4-6 23% -13 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM #18Michigan 8-2 27% -13½ -120FanDuel
Maryland 4-6 73% +14 -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM TCU 6-4 60% +2 -110Bet365
#23Houston 8-2 40% -1 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Kansas State 5-5 73% +17½ -110BetMGM
#12Utah 8-2 27% -17 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Georgia State 1-9 57% +10½ -110Bet365
Troy 6-4 43% -10 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:15 PM Coastal Carolina 6-4 67% +24 -108Caesars
South Carolina 3-7 33% -23½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:30 PM Furman 6-5 - +41½ -110FanDuel
Clemson 5-5 - -41½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/225:00 PM Louisiana-Monroe 3-7 33% +19½ -110Bet365
Texas State 4-6 67% -18 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Pittsburgh 7-3 91% +3 -117BetRivers
#16Georgia Tech 9-1 9% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Nebraska 7-3 63% +9½ -104FanDuel
Penn State 4-6 37% -8 -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Colorado State 2-8 100% +17½ -115BetMGM
Boise State 6-4 0% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM New Mexico 7-3 8% -3½ -102FanDuel
Air Force 3-7 92% +4 -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #20Tennessee 7-3 19% -3½ -118FanDuel
Florida 3-7 81% +4½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM California 6-4 17% -2½ -120FanDuel
Stanford 3-7 83% +3½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #21Illinois 7-3 8% -8 -114BetRivers
Wisconsin 3-7 92% +8½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM North Texas 9-1 22% -17½ -115BetMGM
Rice 5-5 78% +18½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:45 PM Western Kentucky 8-2 67% +22 -112Caesars
LSU 6-4 33% -21½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #11Brigham Young 9-1 14% -2 -110Bet365
Cincinnati 7-3 86% +2½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #25Arizona State 7-3 13% -7 -110Caesars
Colorado 3-7 87% +7½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Washington 7-3 8% -10½ -109Caesars
UCLA 3-7 92% +10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM San Jose State 3-7 88% +12½ -110BetMGM
San Diego State 8-2 12% -12 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Utah State 5-5 100% +3 -113BetRivers
Fresno State 7-3 0% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Massachusetts 0-11 14 +34½ -115BetMGM
Ohio 7-4 42 -33½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Akron 5-7 19 +3 -114BetRivers
Bowling Green 3-8 16 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Western Michigan 7-4 35 -6 -115Bet365
Northern Illinois 3-8 19 +7½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Miami (OH) 6-5 37 -1½ -120BetMGM
Buffalo 5-6 20 +2½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Central Michigan 7-4 28 -7½ -110Bet365
Kent State 4-7 16 +8½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/207:30 PM Louisiana 5-6 34 +3 -120BetRivers
Arkansas State 5-6 30 -2½ -110Bet365

Download the app

NCAAF

Report

The content on this site is for entertainment purposes only. OddsTrader makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. Please be aware of and respect the laws regarding sports betting for your jurisdiction as they vary from state to state. OddsTrader does not target underaged persons. Using this information to contravene any law or statute is prohibited. This site contains commercial content, and OddsTrader may be compensated for the links provided on this site.Disclosure.

OddsTrader is licensed to operate in NJ, NY, PA, IN, CO, IA, IL, VA, WV, TN, CT, MI, AZ, LA, WY, OR, KS, DC, MA & OH.

Seek help with a gambling addiction at 1-800-Gambler.

OddsTrader uses cookies to help us provide, protect & improve our services. See ourPrivacy Policyfor more details.

ACCEPT & CLOSE