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FINAL
Nov 22, 2025 12:00 PM EST
LOU 6 vs SMU 38
Week 13
SMU
-3½ (-110)o49½ (-110)
ESPN2, 209BETCAST
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Louisville Cardinals vs SMU Mustangs Picks
Updated:Nov 22, 2025 2:01 AM EST
The upcoming Saturday football showdown on November 22, 2025, features the Louisville Cardinals visiting the SMU Mustangs at Gerald J. Ford Stadium in Dallas, Texas. This NCAAF regular season Week 13 game is set to be broadcast on ESPN2, providing fans and bettors with a prime viewing opportunity.
Our expert picks for Louisville Cardinals vs SMU Mustangs highlight a predicted final score of SMU 28, Louisville 24, favoring the Mustangs on the moneyline and the point spread at SMU -3.5. The predicted total score leans towards the Over 49.5 with an expected total of 51.8 points. Our betting tips emphasize the strong expected value (EV) and hit rate in the 2-way and point spread markets, especially with the SMU Mustangs showing a 52.8% coverage percentage on the spread.
Over the last 10 games, our prediction model has been profitable, winning 6 of those games in the American Total market and demonstrating a solid hit rate and positive EV. This track record supports the confidence in our picks for this game. Bettors can leverage these insights to make smart wagering decisions, combining our expert analysis with the best odds available.
For more detailed NCAAF picks and analysis, check out our comprehensive NCAAF picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
SMUSpread
CONSENSUS LINE
-4 (-112)
PROJECTION
SMU (28) - LOU (24)
COVER PROBABILITY
EXPECTED VALUE
+0.4%
BET RATING
SEASON COVER %
4/10
40%
EXCLUSIVE BOOSTS
SMU, Kansas, South Florida & Duke All WinSMU to win; Kansas to win; South Florida to win; Duke to win
Missouri, Louisville & Iowa State All WinMissouri to win; Louisville to win; Iowa State to win
Boosts Available
Boosts are special bets with increased odds offered by sportsbooks for a limited time.
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NCAAF Tue 11/25
 Massachusetts 0-11- - | |||||||
 Eastern Michigan 4-7- - | |||||||
 Memphis 8-3- -5½ -112FanDuel | |||||||
 Northern Illinois 3-8- - | |||||||
 Mississippi State 5-6- +9½ -113BetRivers | |||||||
 Nebraska 7-4- +5½ -105FanDuel | |||||||
 Buffalo 5-6- - | |||||||
 Kansas 5-6- +13½ -110FanDuel | |||||||
 Colorado State 2-9- - | |||||||
 #16Georgia Tech 9-2- +13½ -110FanDuel | |||||||
 New Mexico 8-3- +1½ -105FanDuel | |||||||
 North Texas 10-1- -18½ -110FanDuel | |||||||
 Utah State 6-5- - | |||||||
 #17Texas 8-3- +3½ -122FanDuel | |||||||
 Purdue 2-9- +28½ -110FanDuel | |||||||
 #25Arizona State 8-3- +1½ -112FanDuel | |||||||
 Central Michigan 7-4- - | |||||||
 Florida Atlantic 4-7- +5½ -106FanDuel | |||||||
 Louisville 7-4- -3½ -105FanDuel | |||||||
 Oklahoma State 1-10- +15½ -110FanDuel | |||||||
 Miami (OH) 6-5- - | |||||||
 South Carolina 3-7- -2½ -110FanDuel | |||||||
 #18Michigan 9-2- +12½ -110Bet365 | |||||||
 Duke 6-5- -3½ -105FanDuel | |||||||
 West Virginia 4-7- +21½ -122FanDuel | |||||||
 California 6-5- +10½ -110FanDuel | |||||||
 Delaware 5-6- - | |||||||
 Pittsburgh 8-3- +6½ -105FanDuel | |||||||
 Baylor 5-6- -1½ -114FanDuel | |||||||
 #19Virginia 9-2- -11½ -105FanDuel | |||||||
 Sam Houston State 2-9- - | |||||||
 Kansas State 5-6- -18½ -110FanDuel | |||||||
 #11Brigham Young 10-1- -16½ -115FanDuel | |||||||
 TCU 6-4- -4½ -112FanDuel | |||||||
 Marshall 5-6- - | |||||||
 Old Dominion 8-3- - | |||||||
 Jacksonville State 7-4- - | |||||||
 Missouri State 7-4- - | |||||||
 Appalachian State 5-6- - | |||||||
 Texas State 5-6- - | |||||||
 Tulsa 4-7- -7½ -115FanDuel | |||||||
 New Mexico State 4-7- - | |||||||
 Louisiana 5-6- - | |||||||
 Syracuse 3-8- +3½ -115FanDuel | |||||||
 #8Oklahoma 9-2- -10½ +100FanDuel | |||||||
 Arkansas 2-9- +2½ -110FanDuel | |||||||
 Rutgers 5-6- +10½ -105FanDuel | |||||||
 #20Tennessee 8-3- -3½ -102FanDuel | |||||||
 Southern Miss 7-4- -6½ -108FanDuel | |||||||
 Liberty 4-7- - | |||||||
 Minnesota 6-5- -2½ -110FanDuel | |||||||
 Washington 8-3- +6½ +102FanDuel | |||||||
 UTSA 6-5- -6½ -110FanDuel | |||||||
 Coastal Carolina 6-5- +21½ -115FanDuel | |||||||
 Florida 3-8- -4½ -102FanDuel | |||||||
 Washington State 5-6- - | |||||||
 South Florida 8-3- -23½ -115FanDuel | |||||||
 Michigan State 3-8- -4½ -110FanDuel | |||||||
 #24Tulane 9-2- -28½ -105FanDuel | |||||||
 #15USC 8-2- -17½ -110FanDuel | |||||||
 North Carolina State 6-5- -7½ -115FanDuel | |||||||
 #21Illinois 7-4- -6½ -122FanDuel | |||||||
 Auburn 5-6- +6½ -113BetRivers | |||||||
 Nevada 3-8- - | |||||||
 Stanford 4-7- +33½ -115FanDuel | |||||||
 San Jose State 3-8- -2½ -105FanDuel | |||||||
 Hawaii 7-4- - |
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