Ohio State Buckeyes vs Michigan Wolverines Picks

The upcoming showdown on November 29, 2025, between the Ohio State Buckeyes and Michigan Wolverines is set to light up Michigan Stadium in Ann Arbor, MI. This Saturday football event is part of the thrilling 2025-26 NCAAF season and will be broadcasted on FOX, making it a can't-miss for college football fans and sports bettors alike.

Our expert picks for this Ohio State Buckeyes vs Michigan Wolverines game predict a competitive clash with Ohio State edging out Michigan by a score of 27-20. The best bet here is taking Ohio State on the moneyline, as our prediction model shows a 70.3% hit rate for Ohio State wins, which is a strong indicator of confidence. Moreover, the point spread of Michigan +10.5 has a 56.0% coverage percentage, providing valuable betting tips for those looking to parlay or place spread bets.

The total score is predicted to be around 46.36, suggesting that the over 43.5 market, with a 56.2% hit rate and a positive EV of 3.8%, is a profitable avenue for bettors. Our model has been profitable in the last 10 games, particularly in the American Total market, where we have seen a high hit rate and EV, helping bettors make smarter decisions.

For those interested in diving deeper into college football predictions, be sure to check out our comprehensive NCAAF picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.