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The upcoming showdown on November 22, 2025, between the Missouri Tigers and Oklahoma Sooners at Gaylord Family Oklahoma Memorial Stadium in Norman, OK, promises an exciting chapter in the 2025-26 NCAAF season. This Saturday football event will be broadcast on ABC and ESPN Networks, giving fans plenty of viewing options.
The Tigers have shown strength in their passing offense, averaging 208.7 yards per game, but will face a tough Oklahoma pass defense that limits opponents to just 196.2 yards. Meanwhile, Missouri's run offense is impressive at 241.7 yards per game, which will be tested against Oklahoma's run defense holding teams to 82.2 yards on average. Oklahoma boasts a more balanced attack with 226.8 passing yards and 130.7 rushing yards per game, but Missouri's defense allows a moderate 277.5 total yards per game.
Quarterback play will be crucial, with Oklahoma's starter leading a potent offense versus Missouri's solid defensive front. The point spread currently favors Oklahoma by 7.5 points with a total points line of 42.5, indicating a moderately low-scoring but competitive game. Missouri's ATS record is strong at 6-4, while Oklahoma is also 6-4 ATS but struggles more at home with a 2-3 record.
Missouri's recent 49-27 win over Mississippi State highlights their offensive potential, while Oklahoma's 23-21 victory at Alabama shows their resilience. These betting trends and game insights provide a solid foundation for bettors to make informed decisions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
For a look back at their last matchup on November 9, 2024, where Missouri edged Oklahoma 30-23, check out the detailed game recap here.
![]() Ohio 6-423% -33 -110Bet365 | |||||||
Bowling Green 3-748% -2½ -118FanDuel | |||||||
![]() Northern Illinois 3-757% +7 -117BetRivers | |||||||
Buffalo 5-550% +1½ -110Bet365 | |||||||
![]() Kent State 4-681% +9½ -105Bet365 | |||||||
Arkansas State 5-50% -2½ -117Caesars | |||||||
![]() North Carolina State 5-564% +5 -118BetRivers | |||||||
UNLV 8-211% -2½ -110FanDuel | |||||||
![]() #1Ohio State 10-040% -30½ -114FanDuel | |||||||
Army 5-450% -9½ -120FanDuel | |||||||
![]() Wake Forest 7-318% -17 -109BetRivers | |||||||
Virginia Tech 3-775% +18 -117SugarHouse | |||||||
![]() #11Oklahoma 8-236% -7½ -106FanDuel | |||||||
SMU 7-313% -2½ -124FanDuel | |||||||
![]() Iowa State 6-40% -4 -114BetRivers | |||||||
![]() Northwestern 5-50% -3½ -110Bet365 | |||||||
#3Texas A&M 10-0- - | |||||||
![]() #5Georgia 9-155% -43½ -115FanDuel | |||||||
![]() Georgia Southern 5-567% +12½ -110Bet365 | |||||||
![]() James Madison 9-122% -12½ -115FanDuel | |||||||
![]() Arizona 7-314% -6½ -110Bet365 | |||||||
![]() Toledo 6-450% -27 -110BetRivers | |||||||
Wyoming 4-60% -6½ -110Bet365 | |||||||
![]() Kennesaw State 7-320% -6½ -105FanDuel | |||||||
#4Alabama 8-2- - | |||||||
Auburn 4-6- - | |||||||
Appalachian State 4-686% +4½ -109Caesars | |||||||
![]() Florida Atlantic 4-683% +7½ -115Bet365 | |||||||
![]() UTEP 2-825% -3 -110Bet365 | |||||||
![]() Middle Tennessee 1-917% -6½ -115BetMGM | |||||||
![]() Louisiana Tech 5-50% +1½ -118FanDuel | |||||||
UAB 3-775% +21½ -109Caesars | |||||||
![]() North Carolina 4-689% +7 -114BetRivers | |||||||
![]() #10Texas 7-310% -8½ -110FanDuel | |||||||
![]() #8Oregon 9-141% -9½ -115BetMGM | |||||||
#21Iowa 6-422% -16½ -110Bet365 | |||||||
![]() UTSA 5-5100% +2½ -105BetMGM | |||||||
![]() #14Vanderbilt 8-218% -8½ -118SugarHouse | |||||||
![]() South Alabama 3-7100% +2½ -110FanDuel | |||||||
![]() Florida International 5-50% +1½ -120BetMGM | |||||||
#9Notre Dame 8-233% -35 -110Bet365 | |||||||
Temple 5-587% +8½ -113BetRivers | |||||||
UCF 4-625% -14 -105BetMGM | |||||||
Maryland 4-6100% +13½ -105BetMGM | |||||||
![]() Houston 8-20% -1 -114BetRivers | |||||||
![]() #13Utah 8-20% -17 -120Bet365 | |||||||
Troy 6-433% -11 -110Bet365 | |||||||
![]() South Carolina 3-725% -23½ -110FanDuel | |||||||
![]() Clemson 5-5- - | |||||||
Texas State 4-6- -17½ -110Bet365 | |||||||
![]() #16Georgia Tech 9-16% -2½ -110Bet365 | |||||||
![]() Penn State 4-618% -9½ -110Caesars | |||||||
![]() Boise State 6-40% -16½ -110Bet365 | |||||||
Air Force 3-7100% +3½ -114Caesars | |||||||
Florida 3-782% +5 -120BetRivers | |||||||
Stanford 3-791% +3 -109Caesars | |||||||
![]() Wisconsin 3-7100% +8½ -105FanDuel | |||||||
Rice 5-560% +18½ -110Bet365 | |||||||
LSU 6-433% -21½ -110Bet365 | |||||||
![]() #25Cincinnati 7-394% +3 -122SugarHouse | |||||||
![]() Colorado 3-789% +7½ -115Bet365 | |||||||
UCLA 3-775% +10½ -108Caesars | |||||||
San Diego State 8-20% -11½ -110BetMGM | |||||||
![]() Fresno State 7-30% -2½ -113SugarHouse |
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