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The upcoming Saturday football game on November 22, 2025, features the South Alabama Jaguars taking on the Southern Miss Golden Eagles at Hancock Whitney Stadium in Mobile, AL. This NCAAF regular season Week 13 matchup is set to be an exciting contest broadcasted on ESPN+. The South Alabama Jaguars, coming off a 26-14 win against Louisiana-Monroe Warhawks, hold a strong offensive yardage average of 377.4 yards per game, with a balanced attack of 183.1 passing yards and 194.3 rushing yards. Their defense allows 356.6 yards on average. The Southern Miss Golden Eagles, with a 7-3 record, average 409.9 yards offensively and allow 395 yards defensively, indicating a high-scoring potential game.
Quarterback analysis shows South Alabama's starter leading a solid passing offense (183.1 yards) against Southern Miss's defense that allows 223.1 passing yards. Southern Miss's quarterback leads a strong passing attack of 259.1 yards against a South Alabama defense that allows 177.9 passing yards, suggesting a quarterback edge toward Southern Miss. Running games are closely matched, with South Alabama averaging 194.3 rushing yards and Southern Miss 150.8, while defenses show varying strengths in rush defense.
The betting trends reveal Southern Miss as a slight favorite, with a point spread of -1.5 and total points set at 53.5. The Jaguars have a 4-6 ATS record, while Southern Miss holds a 5-4-1 ATS record, pointing to competitive betting action. The Jaguars' home record is less impressive at 1-4 ATS, whereas Southern Miss performs well on the road with a 3-1 straight-up record.
Key players' past performances against each other and recent form suggest Southern Miss's offensive firepower might be the best bet, especially considering their quarterback advantage and stronger pass protection versus South Alabama's pass rush. The total points line at 53.5 suggests a moderately high-scoring game, but bettors should weigh the defensive capabilities carefully.
For smart betting decisions, consider the detailed betting trends and game insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. You can also review the detailed stats from their last matchup on November 23, 2024, where South Alabama won 35-14.
![]() North Carolina State 5-544% +6 -108Caesars | |||||||
UNLV 8-241% -2 -129SugarHouse | |||||||
![]() #1Ohio State 10-030% -31½ -110FanDuel | |||||||
Army 5-436% -9½ -120FanDuel | |||||||
![]() Wake Forest 7-330% -17½ -110Caesars | |||||||
Virginia Tech 3-762% +18½ -113BetRivers | |||||||
![]() #8Oklahoma 8-234% -6½ -110Bet365 | |||||||
SMU 7-324% -2½ -110Bet365 | |||||||
![]() Iowa State 6-435% -3½ -108Caesars | |||||||
![]() Northwestern 5-539% -3½ -110BetMGM | |||||||
#3Texas A&M 10-0- -54½ -110Bet365 | |||||||
![]() #4Georgia 9-148% -43½ -110Bet365 | |||||||
![]() Georgia Southern 5-556% +12½ -115BetMGM | |||||||
![]() James Madison 9-131% -13½ -110Bet365 | |||||||
![]() Arizona 7-330% -6½ -120FanDuel | |||||||
![]() Toledo 6-487% -27½ -110Bet365 | |||||||
Wyoming 4-610% -6½ -112Caesars | |||||||
![]() Kennesaw State 7-322% -6½ -105FanDuel | |||||||
Auburn 4-6- -27½ -110Bet365 | |||||||
#10Alabama 8-2- -50½ -110FanDuel | |||||||
Appalachian State 4-664% +5½ -114Caesars | |||||||
![]() Florida Atlantic 4-688% +7½ -120FanDuel | |||||||
![]() UTEP 2-825% -3 -110Bet365 | |||||||
![]() Middle Tennessee 1-940% -6½ -113BetRivers | |||||||
![]() Louisiana Tech 5-530% +1½ -117SugarHouse | |||||||
UAB 3-772% +21½ -109Caesars | |||||||
![]() North Carolina 4-682% +7 -113Caesars | |||||||
![]() #17Texas 7-315% -8½ -110FanDuel | |||||||
![]() #7Oregon 9-146% -9½ -118SugarHouse | |||||||
Iowa 6-429% -16½ -110Bet365 | |||||||
![]() UTSA 5-581% +2½ -108Caesars | |||||||
![]() #14Vanderbilt 8-211% -8½ -110Caesars | |||||||
![]() South Alabama 3-754% +2½ -110FanDuel | |||||||
![]() Florida International 5-586% +1½ -120Caesars | |||||||
#9Notre Dame 8-267% -35 -110Bet365 | |||||||
Temple 5-578% +9½ -112Caesars | |||||||
UCF 4-623% -13 -110Caesars | |||||||
Maryland 4-673% +14 -107Caesars | |||||||
![]() #23Houston 8-243% -1 -114BetRivers | |||||||
![]() #12Utah 8-226% -17 -110Bet365 | |||||||
Troy 6-443% -10 -110BetMGM | |||||||
![]() South Carolina 3-730% -23½ -122FanDuel | |||||||
![]() Clemson 5-5- -41½ -110FanDuel | |||||||
Texas State 4-667% -18 -113BetRivers | |||||||
![]() #16Georgia Tech 9-18% -2½ -110Bet365 | |||||||
![]() Penn State 4-637% -8 -112Caesars | |||||||
![]() Boise State 6-40% -16½ -110Bet365 | |||||||
Air Force 3-792% +4 -118SugarHouse | |||||||
Florida 3-781% +4½ -115BetMGM | |||||||
Stanford 3-783% +3½ -114Caesars | |||||||
![]() Wisconsin 3-788% +8½ -110BetMGM | |||||||
Rice 5-580% +18½ -114BetRivers | |||||||
LSU 6-431% -21½ -110Bet365 | |||||||
![]() Cincinnati 7-386% +2½ -105Caesars | |||||||
![]() Colorado 3-787% +7½ -114FanDuel | |||||||
UCLA 3-785% +10½ -110Bet365 | |||||||
San Diego State 8-212% -12 -115SugarHouse | |||||||
![]() Fresno State 7-30% -2½ -115Bet365 | |||||||
![]() Ohio 7-442 -33½ -115BetRivers | |||||||
Bowling Green 3-816 -2½ -110Bet365 | |||||||
![]() Northern Illinois 3-819 +7½ -122FanDuel | |||||||
Buffalo 5-620 +2½ -107Caesars | |||||||
![]() Kent State 4-716 +8½ -115FanDuel | |||||||
Arkansas State 5-630 -2½ -110Bet365 |
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