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FINAL
Sep 27, 2025 7:00 PM EDT
ARIZ 14 vs ISU 39
Week 5
9-4
Arizona
14
FINAL
39
8-4
#14 Iowa State
ISU
-4 (-105)o48 (-110)
tvESPN, 206
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Arizona Wildcats vs Iowa State Cyclones Picks

Updated:Sep 26, 2025 5:27 AM EDT

Get ready for an exciting showdown as the Arizona Wildcats face off against the Iowa State Cyclones on September 27, 2025, at the iconic Jack Trice Stadium in Ames, IA. As part of the NCAAF's thrilling Week 5, this Saturday football clash promises to deliver high-octane action. The game will be broadcasted on ESPN, making it a must-watch event for college football fans and bettors alike.

Our expert picks suggest that the Iowa State Cyclones are favored to win, with a predicted score of 28-24. Considering the point spread, Arizona +6.5 offers a promising opportunity for bettors, boasting a 53.3% hit rate and a positive EV. Historically, our predictions in similar matchups have been highly successful, with a strong track record of profitable bets.

For those looking to delve deeper into the world of sports betting, our OddsTrader Turbo subscription provides invaluable insights and strategies. Explore OddsTrader Turbo now to gain an edge in your betting decisions. Also, check out our latest NCAAF picks for more expert analysis.

Ready to place your bets? Our prediction model suggests favorable odds for the Arizona Wildcats to cover the spread, making this an enticing wager. Don't miss out on the action and make sure to tune in to ESPN for live coverage.

What are the picks for Arizona vs Iowa State?
UPCOMING GAME PREDICTION
Spread
Money
Total
team
ISUSpread
CONSENSUS LINE
-5 (-110)
PROJECTION
ARIZ (24) - ISU (28)
COVER PROBABILITY
51%
EXPECTED VALUE
-0.0%
BET RATING
SEASON COVER %
2/4
50%
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