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FINAL
Oct 25, 2025 7:30 PM EDT
BC 24 vs LOU 38
Week 9
2-10
Boston College
24
FINAL
38
9-4
#16 Louisville
LOU
-25½ (-110)o54½ (-110)
tvACC Network, 612
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Boston College Eagles vs Louisville Cardinals Betting Trends

Updated:Oct 25, 2025 2:21 AM EDT

Get ready for Saturday football excitement as the Boston College Eagles face off against the Louisville Cardinals on October 25, 2025, at L&N Federal Credit Union Stadium in Louisville, KY. This 2025-26 NCAAF matchup promises thrilling betting trends to watch. Louisville holds a strong home record of 3-1 and averages 397.8 total yards per game, boasting a solid pass offense with 282.2 yards. Boston College counters with a balanced offense, averaging 372.6 total yards and a strong pass defense allowing just 170.5 yards. The Cardinals' starting quarterback leads a dynamic offense with 34 points per game, while the Eagles rely on a resilient defense that ranks high in sacks and interceptions.

Comparing the teams’ run offense and defense, Louisville averages 115.7 rushing yards against Boston College's 100.1, offering bettors insights into the ground game battle. Pass protection vs pass rush stats reveal Louisville’s offensive line faces a tough Eagles pass rush, which could influence scoring. The spread is set at Louisville -25.5, with a total points over/under of 54.5, suggesting a high-scoring game. This data-driven analysis provides bettors with key betting stats for making informed wagers.

Don’t miss the live broadcast on ACC Network to catch all the action. For a deeper dive into betting trends and sports insights, check out the full game preview. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

What is the significance of the point spread in this game?

ATS Records

Boston College

Louisville

All
  • All
  • 1st half
  • 2nd half
  • 1st quarter
  • 2nd quarter
  • 3rd quarter
  • 4th quarter
6-6 (145th)Against the Spread4-9 (246th)
2-10 (238th)Straight Up9-4 (57th)
-9.3Straight Up Units+1.5
7-4-1Over / Under6-7

TEAM MATCHUP

Boston College

Louisville

OFF
DEF
OFF
DEF
25.4Points29.9
383.4Total Yards384.5
5.3Yards Per Play6
280.2Passing Yards220.6
23.9 - 37.8 (63.2%)Completions-Attempts20.6 - 32.2 (64.1%)
7.4Yards Per Passing Play6.9
18.8Sacks-Yards Lost13.9
103.3Rushing Yards163.9
31.4Attempts32.4
3.3Yards Per Rush5.1
20.81st Downs19.8
12.4Passing9.6
6.8Rushing8.5
1.7Penalties1.7
5.3 / 13.8 (38.6%)3rd Down4.5 / 12.8 (35.3%)
1.3 / 2.6 (51.6%)4th Down0.7 / 1.1 (64.3%)
3.1 / 3.6 (86%)Red Zone2.9 / 3.2 (90.5%)
5.9 (49.7)Penalties (Yards)6.9 (63.2)
1Interceptions0.7
0.8Fumbles Lost0.6
72.3Total Plays66.5
5.1Kickoffs6.2
1.7Returns1.3
31.3Yards28.3
18.8Yards Per Return21.6
4.3Punts4.4
1.2Returns2.3
11.4Yards38.5
9.8Yards Per Return16.7

Recent Results

Boston College

Louisville

Game
Score
ATS
O/U
vs Connecticut
Oct 18, 2025
L
23-38
L
+2
O
57½
vs Clemson
Oct 11, 2025
L
10-41
L
+14
U
54½
at Pittsburgh
Oct 4, 2025
L
7-48
L
+7
P
55
vs California
Sep 27, 2025
L
24-28
L
-6
U
54
at Stanford
Sep 13, 2025
L
20-30
L
-14
O
45
at Michigan State
Sep 6, 2025
L
40-42
W
+3½
O
45½
vs Fordham
Aug 30, 2025
W
66-10
W
-34½
O
53½
at Nebraska
Dec 28, 2024
L
15-20
L
+3½
U
47½
vs Pittsburgh
Nov 30, 2024
W
34-23
W
-4
O
50½
vs North Carolina
Nov 23, 2024
W
41-21
W
+2½
O
50½
Game
Score
ATS
O/U
at Miami (FL)
Oct 17, 2025
W
24-21
W
+10½
U
49½
vs Virginia
Oct 4, 2025
L
27-30
L
-6½
U
60½
at Pittsburgh
Sep 27, 2025
W
34-27
W
-3
O
54½
vs Bowling Green
Sep 20, 2025
W
40-17
L
-26½
O
51½
vs James Madison
Sep 5, 2025
W
28-14
L
-14½
U
56½
vs Eastern Kentucky
Aug 30, 2025
W
51-17
L
-38½
O
56½
at Washington
Dec 31, 2024
W
35-34
W
+1
O
50½
at Kentucky
Nov 30, 2024
W
41-14
W
-4½
O
49½
vs Pittsburgh
Nov 23, 2024
W
37-9
W
-7
U
57½
at Stanford
Nov 16, 2024
L
35-38
L
-21
O
57½
View Full Season Game Log

HEAD TO HEAD

Boston College

BC

Louisville

LOU
Matchup
SU
ATS
O/U
Louisville @ Boston CollegeOct 25, 2024
31-27
LOU
+7
BC
53½
O
Boston College @ LouisvilleSep 23, 2023
28-56
LOU
-14
LOU
53½
O
Louisville @ Boston CollegeOct 1, 2022
33-34
BC
+13½
BC
48½
O
Boston College @ LouisvilleOct 23, 2021
14-28
LOU
-4
LOU
57½
U
Louisville @ Boston CollegeNov 28, 2020
27-34
BC
-1
BC
57
O

Boston College

UPCOMING SCHEDULE

Louisville

Matchup
Date
Time
vs Notre Dame
tvESPN, 206
Nov 1, 2025
15:30 EDT
vs SMU
tvACC Network, 612
Nov 8, 2025
12:00 EST
vs Georgia Tech
tvACC Network, 612
Nov 15, 2025
15:30 EST
at Syracuse
tvThe CW
Nov 29, 2025
15:00 EST
Matchup
Date
Time
at Virginia Tech
tvThe CW
Nov 1, 2025
15:00 EDT
vs California
tvESPN2, 209, ESPN Networks
Nov 8, 2025
19:00 EST
vs Clemson
tvESPN, 206
Nov 14, 2025
19:30 EST
at SMU
tvESPN2, 209
Nov 22, 2025
12:00 EST
vs Kentucky
tvESPN Networks, ACC Network, 612
Nov 29, 2025
12:00 EST
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