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Get ready for an exciting matchup as the Boston College Eagles take on the Michigan State Spartans on September 6, 2025, at Spartan Stadium in East Lansing, MI. This Saturday football clash is sure to keep fans on the edge of their seats, with the game airing on NBC. Our picks favor Michigan State to edge out Boston College with a predicted score of 25-23. Our prediction model indicates Michigan State has a slight edge with a 52.9% chance of winning in a 2-way market, while the over 45.5 market shows a promising 56.4% hit rate. Historically, our predictions have been profitable, and we've had success in American Totals, hitting 6 out of the last 10 games. Check out our NCAAF picks page for more insights and betting tips. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.