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The upcoming Saturday football game on November 22, 2025, features a compelling matchup between the Eastern Washington Eagles and the Cal Poly Mustangs at Mustang Memorial Field in San Luis Obispo, CA. This NCAAF regular season Week 13 game is a must-watch for fans and bettors alike, airing on espn+.
Eastern Washington enters the contest with a solid 5-6 straight-up record and a strong 7-4 against the spread (ATS) performance, including a 4-2 ATS away record. Cal Poly, on the other hand, holds a 3-8 straight-up record and a balanced 5-5 ATS record, boasting a 2-1 ATS record at home. The Mustangs have shown resilience in recent games but have struggled to secure wins consistently.
Examining the betting trends, Eastern Washington has historically dominated Cal Poly, including a recent 48-13 victory on November 4, 2023, at Roos Field, Cheney, WA, which you can review in their last matchup. The Eagles' defense has been effective, allowing just 29 points per game on average, while their offense averages 341.7 total yards per game. Cal Poly's defense allows slightly more yards, with 435.5 total yards per game, but their offense is less productive, averaging 370.9 yards per game. The Eagles' passing offense (216 yards) faces off against Cal Poly's pass defense (248 yards allowed), presenting a competitive edge for the Mustangs' defense.
Quarterback play will be crucial, with both teams expected to start their primary quarterbacks. The offensive lines' ability to protect their quarterbacks against the pass rush will be a key factor. The odds spread and total points are yet to be announced, but bettors should consider these stats to make informed bets. The Eagles' ability to control the run game and pressure the quarterback could tilt the game in their favor.
For bettors looking to capitalize on this exciting matchup, the best odds available today for Eastern Washington and Cal Poly can be found at top U.S. regulated sportsbooks, with detailed betting insights and trends available. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
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