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FINAL
Sep 20, 2025 12:00 PM EDT
SYR 34 vs CLEM 21
Week 4
CLEM
-18 (-109)o53½ (-105)
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Syracuse Orange vs Clemson Tigers Picks
Updated:Sep 20, 2025 5:29 AM EDT
The Syracuse Orange are set to take on the Clemson Tigers in a thrilling matchup scheduled for September 20, 2025, at Memorial Stadium in Clemson, SC. As part of the NCAAF league, this game promises excitement on the field and in the betting markets. The game will be broadcasted on ESPN, ensuring fans won't miss a moment of the action.
Our expert picks predict a close contest, with Clemson favored to win. The predicted score is Clemson 34, Syracuse 20. The spread is set at Clemson -16.5, but our model suggests Syracuse could cover with a hit rate of 54.8% and an EV of 3.1%. The total score prediction is just under the line at 54.8, suggesting a potential under 55.5 bet could be a smart play.
Our prediction model has been profitable in the last 10 games, with a strong performance in the point spread market. With a high EV and consistent hit rate, bettors can feel confident in leveraging these insights for smart wagers. Whether you're placing a bet with a U.S. regulated sportsbook or ready to Start your OddsTrader Turbo subscription, our insights are here to give you the edge. Check out more NCAAF insights on our league picks page.
UPCOMING GAME PREDICTION
Spread
Money
Total
SYRSpread
CONSENSUS LINE
+17½ (-120)
PROJECTION
SYR (20) - CLEM (34)
COVER PROBABILITY
EXPECTED VALUE
+4.5%
BET RATING
SEASON COVER %
1/3
33%
NCAAF
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NCAAFWeek 1
NCAAF Sat 08/29
 TCU - -6½ -110Bovada | |||||||
 Valparaiso - - | |||||||
 USC - -35½ -108Heritage | |||||||
 Virginia - -3 -110MyBookie | |||||||
 North Dakota State - -8½ -105BetOnline | |||||||
 Eastern Michigan - -7½ -110Bovada | |||||||
 Florida State - -30½ -108Heritage | |||||||
 Stanford - -3½ -108Heritage | |||||||
 UNLV - -3 -115Bookmaker | |||||||
 Rutgers - -30½ -108Heritage | |||||||
 Wake Forest - -22½ -108Heritage | |||||||
 Kennesaw State - - | |||||||
 Buffalo - - | |||||||
 Delaware - - | |||||||
 UCF - - | |||||||
 Georgia Tech - -7 -110BetOnline | |||||||
 Minnesota - - | |||||||
 Missouri - - | |||||||
 Illinois - -27½ -108Heritage | |||||||
 Utah - - | |||||||
Eastern Michigan - -3½ -108Heritage | |||||||
 Georgia State - - | |||||||
 Purdue - - | |||||||
 Michigan State - -10½ -105BetOnline | |||||||
 Kansas - - | |||||||
USC - -22½ -110BetOnline | |||||||
Stanford - +23 -105BetOnline | |||||||
 West Virginia - -17½ -105BetOnline | |||||||
 James Madison - -6 -110BetOnline | |||||||
 Indiana - -39½ -108Heritage | |||||||
 Alabama - -26½ -108Heritage | |||||||
 Nebraska - -23½ -105BetOnline | |||||||
 Houston - -18½ -108Heritage | |||||||
 Connecticut - - | |||||||
 Syracuse - - | |||||||
 Bowling Green - - | |||||||
 Army - - | |||||||
 Pittsburgh - -15½ -110Bovada | |||||||
 Ohio State - -49½ -110BetOnline | |||||||
 South Carolina - -34½ -108Heritage | |||||||
 Oklahoma - -40½ -105BetOnline | |||||||
 Iowa State - - | |||||||
 Kentucky - - | |||||||
 Air Force - - | |||||||
 Temple - - | |||||||
 Georgia - - | |||||||
 Cincinnati - -7½ -108Heritage | |||||||
 Penn State - -22½ -110BetOnline | |||||||
 Duke - -8 -110Bookmaker | |||||||
 Texas - -30½ -110BetOnline | |||||||
 Oregon - -24½ -108Heritage | |||||||
 Auburn - -7 -105Bookmaker | |||||||
 Tennessee - - | |||||||
 Appalachian State - - | |||||||
 Charlotte - - | |||||||
 UTSA - - | |||||||
North Dakota State - - | |||||||
 Navy - - | |||||||
 Tulsa - +12½ -108Heritage | |||||||
 Iowa - -30 -110Bookmaker | |||||||
 Arkansas - - | |||||||
 Southern Miss - - | |||||||
 Colorado State - -3½ -108Heritage | |||||||
 Old Dominion - - | |||||||
 South Florida - -12 -108Heritage | |||||||
 Texas A&M - -38½ -110BetOnline | |||||||
 Troy - -17 -112Bookmaker | |||||||
 Memphis - -10½ -108Heritage | |||||||
 South Alabama - - | |||||||
 Middle Tennessee - - | |||||||
 Kansas State - - | |||||||
 Utah State - - | |||||||
 Jacksonville State - - | |||||||
 Vanderbilt - - | |||||||
 Georgia Southern - - | |||||||
 Texas Tech - - | |||||||
 Rice - - | |||||||
 Michigan - -26½ -108Heritage | |||||||
 Mississippi State - -28 -110Bookmaker | |||||||
 LSU - -11 -110MyBookie | |||||||
 Virginia Tech - - | |||||||
 Louisiana Tech - - | |||||||
 Florida - -26 -110BetOnline | |||||||
 Northwestern - - | |||||||
 Louisiana - - | |||||||
 Maryland - - | |||||||
 Brigham Young - - | |||||||
 New Mexico State - - | |||||||
 Arizona - - | |||||||
 San Diego State - - | |||||||
 New Mexico - -12 -108Heritage | |||||||
 Hawaii - +2½ -110MyBookie | |||||||
 Arizona State - - | |||||||
 Sacramento State - - | |||||||
 California - PK -110BetOnline | |||||||
 Nevada - +3½ -115BetOnline | |||||||
 Washington - -21½ -108Heritage | |||||||
 Notre Dame - -20½ -108Heritage | |||||||
 Ole Miss - -4½ -110BetOnline | |||||||
Florida State - +3 -115BetOnline |
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