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Get ready for a thrilling clash on October 4, 2025, as the Colorado Buffaloes take on the TCU Horned Frogs at Amon G. Carter Stadium in Fort Worth, TX. This exciting Saturday football matchup is set to broadcast on FOX, bringing together two teams with a history of close encounters. In their last meeting on September 2, 2023, the Buffaloes edged out the Horned Frogs with a 45-42 victory. As of now, TCU is favored with a -13.5 point spread on Caesars, a testament to their strong home record. The Horned Frogs have a potent pass offense, averaging 320.75 passing yards per game, which will test Colorado's defense. Meanwhile, the Buffaloes' balanced offense, led by their starting quarterback, aims to exploit any gaps in TCU's defense. With an over/under set at 57.5 points, bettors should consider the high-scoring potential of this encounter. Both teams have had mixed results recently, making this a must-watch for sports betting enthusiasts. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.