Wyoming Cowboys vs Colorado Buffaloes Odds

Before the big clash on September 20, 2025, between the Wyoming Cowboys and Colorado Buffaloes at Folsom Field in Boulder, CO, fans and bettors alike are buzzing with anticipation. The Colorado Buffaloes, playing in their home stadium, are the favorites with a point spread of -13 -115. Meanwhile, the Wyoming Cowboys are the underdogs with a spread of +13 -105. This game promises to be an exciting encounter in the NCAAF league, especially with the game airing on ESPN. Bettors should note the opening odds favored the Buffaloes, and the line has held steady, indicating confidence in their home advantage. For those looking to bet, the Moneyline stands at +360 for the Cowboys and -480 for the Buffaloes, making it a potentially lucrative wager for risk-takers betting on an upset. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more insights, check out our NCAAF odds page.