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The much-anticipated Saturday football game on November 22, 2025, features the Duke Blue Devils visiting the North Carolina Tar Heels at Kenan Stadium in Chapel Hill, NC. This NCAAF regular season Week 13 matchup promises intense rivalry action and high stakes as both teams battle for conference supremacy.
Our expert picks favor Duke with a predicted score of 28 to 24 over North Carolina. The best bet is Duke +2.5 on the point spread, boasting a strong hit rate of 61.6% and a high EV of 9.2%. This betting tip is supported by our prediction model which has been profitable in recent games, especially in point spread markets, helping bettors make smarter wagers.
Fans can catch the action live on ACC Network, bringing all the excitement directly to your screens. The game is set at Kenan Stadium, a renowned outdoor venue known for its electric atmosphere during college football clashes.
For those looking to dive deeper, explore our comprehensive NCAAF picks and predictions to stay ahead of the game. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
TCU - -6½ -110Bovada | |||||||
![]() Valparaiso - - | |||||||
USC - -35½ -108Heritage | |||||||
![]() Virginia - -3 -110MyBookie | |||||||
![]() North Dakota State - -8½ -105BetOnline | |||||||
Eastern Michigan - -7½ -110Bovada | |||||||
Florida State - -30½ -108Heritage | |||||||
Stanford - -3½ -108Heritage | |||||||
UNLV - -3 -115Bookmaker | |||||||
Rutgers - -30½ -108Heritage | |||||||
![]() Wake Forest - -22½ -108Heritage | |||||||
![]() Kennesaw State - - | |||||||
Buffalo - - | |||||||
![]() Delaware - - | |||||||
UCF - - | |||||||
![]() Georgia Tech - -7 -110BetOnline | |||||||
Minnesota - - | |||||||
![]() Missouri - - | |||||||
Illinois - -27½ -108Heritage | |||||||
![]() Utah - - | |||||||
Eastern Michigan - -3½ -108Heritage | |||||||
Georgia State - - | |||||||
![]() Purdue - - | |||||||
Michigan State - -10½ -105BetOnline | |||||||
![]() Kansas - - | |||||||
USC - -22½ -110BetOnline | |||||||
Stanford - +23 -105BetOnline | |||||||
West Virginia - -17½ -105BetOnline | |||||||
![]() James Madison - -6 -110BetOnline | |||||||
![]() Indiana - -39½ -108Heritage | |||||||
Alabama - -26½ -108Heritage | |||||||
Nebraska - -23½ -105BetOnline | |||||||
![]() Houston - -18½ -108Heritage | |||||||
![]() Connecticut - - | |||||||
Syracuse - - | |||||||
Bowling Green - - | |||||||
Army - - | |||||||
![]() Pittsburgh - -15½ -110Bovada | |||||||
![]() Ohio State - -49½ -110BetOnline | |||||||
![]() South Carolina - -34½ -108Heritage | |||||||
![]() Oklahoma - -40½ -105BetOnline | |||||||
![]() Iowa State - - | |||||||
Kentucky - - | |||||||
Air Force - - | |||||||
Temple - - | |||||||
![]() Georgia - - | |||||||
![]() Cincinnati - -7½ -108Heritage | |||||||
![]() Penn State - -22½ -110BetOnline | |||||||
![]() Duke - -8 -110Bookmaker | |||||||
![]() Texas - -30½ -110BetOnline | |||||||
![]() Oregon - -24½ -108Heritage | |||||||
Auburn - -7 -105Bookmaker | |||||||
Tennessee - - | |||||||
Appalachian State - - | |||||||
![]() Charlotte - - | |||||||
![]() UTSA - - | |||||||
![]() North Dakota State - - | |||||||
Navy - - | |||||||
![]() Tulsa - +12½ -108Heritage | |||||||
Iowa - -30 -110Bookmaker | |||||||
![]() Arkansas - - | |||||||
Southern Miss - - | |||||||
![]() Colorado State - -3½ -108Heritage | |||||||
![]() Old Dominion - - | |||||||
![]() South Florida - -12 -108Heritage | |||||||
Texas A&M - -38½ -110BetOnline | |||||||
Troy - -17 -112Bookmaker | |||||||
![]() Memphis - -10½ -108Heritage | |||||||
![]() South Alabama - - | |||||||
![]() Middle Tennessee - - | |||||||
![]() Kansas State - - | |||||||
![]() Utah State - - | |||||||
![]() Jacksonville State - - | |||||||
![]() Vanderbilt - - | |||||||
![]() Georgia Southern - - | |||||||
![]() Texas Tech - - | |||||||
Rice - - | |||||||
![]() Michigan - -26½ -108Heritage | |||||||
![]() Mississippi State - -28 -110Bookmaker | |||||||
LSU - -11 -110MyBookie | |||||||
Virginia Tech - - | |||||||
![]() Louisiana Tech - - | |||||||
Florida - -26 -110BetOnline | |||||||
![]() Northwestern - - | |||||||
![]() Louisiana - - | |||||||
Maryland - - | |||||||
Brigham Young - - | |||||||
New Mexico State - - | |||||||
![]() Arizona - - | |||||||
San Diego State - - | |||||||
![]() New Mexico - -12 -108Heritage | |||||||
![]() Hawaii - +2½ -110MyBookie | |||||||
![]() Arizona State - - | |||||||
![]() Sacramento State - - | |||||||
![]() California - PK -110BetOnline | |||||||
![]() Nevada - +3½ -115BetOnline | |||||||
![]() Washington - -21½ -108Heritage | |||||||
Notre Dame - -20½ -108Heritage | |||||||
![]() Ole Miss - -4½ -110BetOnline | |||||||
Florida State - +3 -115BetOnline |