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As we gear up for the exciting matchup between the Duke Blue Devils and Tulane Green Wave on September 13, 2025, both teams are looking to make a statement in the NCAAF season. The game will take place at the Yulman Stadium in New Orleans, LA, and will be aired on ESPN2. Duke has had a mixed start to the season, with their recent loss to Illinois, where they failed to cover the spread. Their quarterback play, however, remains a strong point with promising passing yards. On the other hand, Tulane enters the game with an unblemished record, coming off a win against South Alabama. Their running game has been particularly impressive, posing a challenge to Duke’s defense. With Tulane favored by 1.5 points and a total points line set at 52.5, bettors have plenty to consider. Duke's ATS record is less than stellar, but their offensive potential shouldn't be underestimated. The betting trends suggest a close game with potential for high scoring, especially considering Tulane's dynamic offense. If you're looking to bet smarter, Start your OddsTrader Turbo subscription now or place your wager with a U.S. regulated sportsbook.