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On October 11, 2025, the Eastern Illinois Panthers are set to face off against the Gardner-Webb Runnin' Bulldogs at O'Brien Field in Charleston, IL. This exciting NCAAF match promises to be a thrilling encounter. The Panthers, with a predicted score of 28, are slightly favored with a +4.5 spread, boasting a coverage hit rate of 59.4% and an EV of 7.0%. Meanwhile, the Bulldogs are expected to score 30 points, making this a closely contested game. Our prediction model suggests that betting on the Panthers' spread could be a smart move. Catch the action live on ESPN+ and explore our NCAAF picks for more insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.