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FINAL
Oct 18, 2025 1:00 PM EDT
EIU 13 vs SEMO 42
Week 8
3-9
Eastern Illinois
13
FINAL
42
4-8
Southeast Missouri State
SEMO
-7 (-115)o53 (-125)
tvESPN+
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Eastern Illinois Panthers vs Southeast Missouri State Redhawks Betting Trends

Updated:Oct 18, 2025 3:47 AM EDT

The upcoming Saturday football game on October 18, 2025, features the Eastern Illinois Panthers taking on the Southeast Missouri State Redhawks at Houck Field in Cape Girardeau, MO. This highly anticipated NCAAF regular season Week 8 matchup is set to be broadcast on ESPN+, giving fans excellent access to the action. The Panthers enter the game with a solid offensive output, averaging 341.2 total yards per game, led by a passing offense that generates 176 yards and a rushing game contributing 165 yards. Their defense has been stout, allowing just 366 total yards, with a balanced approach to stopping both the pass and the run. Meanwhile, the Redhawks boast a stronger passing offense with 260.7 yards per game but have struggled defensively, surrendering 476 yards on average. Their run defense has been a vulnerability, allowing 201.8 rushing yards per game, which could be exploited by the Panthers' rushing attack.

The Panthers' starting quarterback, despite being listed as questionable, is expected to play, which is a crucial factor given the quarterback's influence on the passing game and overall team rhythm. The Redhawks' defense faces challenges in pass protection as they allow an average of 5.5 sacks per game, which may give the Panthers' pass rush an advantage. The odds for this game are currently not listed, but bettors should watch for a spread that reflects the Panthers' balanced offense against the Redhawks' defensive struggles. Total points should also be considered given the offensive capabilities of both teams.

In their last matchup on October 5, 2024, the Southeast Missouri State Redhawks defeated the Eastern Illinois Panthers 38-27, a game that went over the total points line of 50.5. This history adds an exciting layer to the betting trends and game insights for this upcoming encounter. The Redhawks have a 2-4 straight-up record at home this season, while the Panthers are 1-1 as away underdogs, with a 4-2 record against the spread overall. These betting stats suggest potential value in favor of the Panthers covering the spread.

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When is the Eastern Illinois Panthers vs Southeast Missouri State Redhawks game?

ATS Records

Eastern Illinois

Southeast Missouri State

All
  • All
  • 1st half
  • 2nd half
  • 1st quarter
  • 2nd quarter
  • 3rd quarter
  • 4th quarter
6-6 (144th)Against the Spread4-8 (237th)
3-9 (222nd)Straight Up4-8 (206th)
-5.9Straight Up Units-7.1
4-8Over / Under4-8

TEAM MATCHUP

Eastern Illinois

Southeast Missouri State

OFF
DEF
OFF
DEF
17.5Points23.2
297.3Total Yards347.8
5Yards Per Play4.7
165.1Passing Yards263.3
14.3 - 25.2 (57%)Completions-Attempts23.9 - 39.2 (61.1%)
6.6Yards Per Passing Play6.7
2.3Sacks-Yards Lost4.8
132.3Rushing Yards84.5
38.3Attempts31.7
3.5Yards Per Rush2.7
17.21st Downs19.6
6.6Passing9.9
6.9Rushing4.4
1.5Penalties1.8
4.3 / 13.3 (32.5%)3rd Down6 / 15.8 (38.1%)
0.6 / 1.8 (31.8%)4th Down1.1 / 1.8 (59.1%)
2.2 / 2.9 (74.3%)Red Zone2.4 / 2.6 (93.5%)
4.8 (39.8)Penalties (Yards)7.5 (69.7)
1Interceptions0.8
0.3Fumbles Lost1.1
66.8Total Plays74.6
3.8Kickoffs4.6
2Returns2.4
35.1Yards48.3
17.5Yards Per Return20
4.8Punts6
1.8Returns2
17.4Yards15
10Yards Per Return7.5

Recent Results

Eastern Illinois

Southeast Missouri State

Game
Score
ATS
O/U
vs Gardner-Webb
Oct 11, 2025
L
10-21
L
+4½
U
58½
vs Tennessee State
Oct 4, 2025
W
31-7
W
-6
U
50½
at Western Illinois
Sep 27, 2025
W
31-23
W
+2½
U
62
vs Illinois State
Sep 13, 2025
L
30-42
W
+20½
O
50½
at Indiana State
Sep 6, 2025
L
14-38
L
+3½
O
50½
vs Dayton
Aug 28, 2025
W
24-14
W
-8½
U
47½
at Tennessee Tech
Nov 23, 2024
L
6-23
L
+12½
U
46½
vs Charleston Southern
Nov 16, 2024
W
16-13
L
-5
U
47½
at Gardner-Webb
Nov 9, 2024
L
28-31
W
+4½
O
54½
vs Western Illinois
Nov 2, 2024
W
45-38
W
-5½
O
61½
Game
Score
ATS
O/U
vs Tennessee State
Oct 11, 2025
W
28-12
L
-16½
U
51½
at Tennessee-Martin
Sep 27, 2025
L
10-34
L
-3
U
56½
vs Southern Illinois
Sep 20, 2025
L
31-59
L
+5½
O
54½
at North Dakota State
Sep 13, 2025
L
14-41
W
+32½
U
56½
vs North Alabama
Sep 6, 2025
W
30-21
L
-16½
U
55½
at Arkansas State
Aug 30, 2025
L
24-42
L
+14½
O
59½
at Tennessee State
Nov 23, 2024
L
21-28
L
-7
U
50½
vs Western Illinois
Nov 16, 2024
W
54-45
L
-21½
O
63½
at Lindenwood University
Nov 9, 2024
L
12-24
L
-16½
U
56½
View Full Season Game Log

HEAD TO HEAD

Eastern Illinois

EIU

Southeast Missouri State

SEMO
Matchup
SU
ATS
O/U
Southeast Missouri State @ Eastern IllinoisOct 5, 2024
38-27
SEM
-10½
SEM
50½
O
Eastern Illinois @ Southeast Missouri StateOct 14, 2023
28-35
SEM
+13½
EIL
49½
O
Southeast Missouri State @ Eastern IllinoisNov 12, 2022
31-7
SEM
-20
SEM
58½
U
Eastern Illinois @ Southeast Missouri StateOct 30, 2021
15-38
SEM
-14
SEM
49
O
Southeast Missouri State @ Eastern IllinoisFeb 28, 2021
47-7
SEM
-12½
SEM
49½
O

Eastern Illinois

UPCOMING SCHEDULE

Southeast Missouri State

Matchup
Date
Time
at Charleston Southern
tvESPN+
Oct 25, 2025
14:00 EDT
vs Tennessee-Martin
tvESPN+
Nov 1, 2025
15:00 EDT
vs Tennessee Tech
tvESPN+
Nov 8, 2025
13:00 EST
at Lindenwood University
tvESPN+
Nov 15, 2025
15:00 EST
at Alabama
tvSEC Network+
Nov 22, 2025
14:00 EST
Matchup
Date
Time
at Tennessee Tech
tvESPN+
Oct 25, 2025
13:00 EDT
vs Charleston Southern
tvESPN+
Nov 1, 2025
14:00 EDT
at Gardner-Webb
tvESPN+
Nov 8, 2025
13:30 EST
at Western Illinois
tvESPN+
Nov 15, 2025
14:00 EST
vs Lindenwood University
tvESPN+
Nov 22, 2025
14:00 EST
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