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FINAL
Sep 20, 2025 7:30 PM EDT
ILL 10 vs IND 63
Week 4
9-4
#23 Illinois
10
FINAL
63
16-0
#11 Indiana
IND
-7 (-105)o51½ (-110)
tvNBC
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Illinois Vs Indiana Betting Trends

Updated:Sep 20, 2025 6:27 AM EDT

As the Illinois Fighting Illini prepare to face the Indiana Hoosiers on September 20, 2025, at Memorial Stadium in Bloomington, IN, fans and bettors alike are gearing up for what promises to be a thrilling NCAAF showdown. With both teams boasting undefeated records, this matchup is a must-watch, especially for those looking to capitalize on the latest betting trends.

The Hoosiers, led by their dynamic quarterback, have shown an impressive offensive display, averaging 591.7 total yards per game. Their passing offense, which racks up 284 yards per game, could pose a significant challenge to the Illini's defense, which has been solid but will need to up their game to contain Indiana's explosive plays. On the other hand, Illinois, known for their strategic play and a robust run offense averaging 164.7 rushing yards per game, will look to exploit Indiana's defense, which has allowed 115.3 rushing yards per game. This battle of strategies makes for an exciting Saturday football event, broadcasted live on NBC.

In their last matchup on November 11, 2023, the Illini narrowly edged out the Hoosiers with a 48-45 victory. With odds currently favoring Indiana at -6.5 and a total points line set at 52.5, bettors should keep a close eye on the point spread and total points. Understanding these betting insights can aid in making informed wagers, especially when considering the ATS records available on our NCAAF standings page.

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Who is favored to win between Illinois and Indiana?

ATS Records

Illinois

Indiana

All
  • All
  • 1st half
  • 2nd half
  • 1st quarter
  • 2nd quarter
  • 3rd quarter
  • 4th quarter
8-4-1 (46th)Against the Spread10-6 (43rd)
9-4 (55th)Straight Up16-0 (1st)
+1.0Straight Up Units+6.1
5-8Over / Under10-6

TEAM MATCHUP

Illinois

Indiana

OFF
DEF
OFF
DEF
29.4Points41.6
373.8Total Yards452
6.1Yards Per Play7.3
235.8Passing Yards239.1
19.3 - 28.6 (67.5%)Completions-Attempts18.3 - 25.4 (71.9%)
8.2Yards Per Passing Play9.4
17.5Sacks-Yards Lost10.3
138.1Rushing Yards212.9
35.2Attempts41.2
3.9Yards Per Rush5.2
21.21st Downs23.8
10.4Passing10.6
8.5Rushing11.5
2.4Penalties1.6
4.9 / 11.7 (42.1%)3rd Down7.1 / 12.5 (56.5%)
1 / 1.8 (56.5%)4th Down0.6 / 1.1 (55.6%)
3.7 / 4.3 (85.7%)Red Zone4.4 / 4.8 (92.2%)
4.6 (39.5)Penalties (Yards)3.8 (27.6)
0.5Interceptions0.4
0.4Fumbles Lost0.1
66.3Total Plays68.1
5.7Kickoffs7.6
0.8Returns0.6
18.8Yards13
22.3Yards Per Return20.8
2.8Punts2.7
1Returns1.6
16.4Yards25.9
16.4Yards Per Return16.6

Recent Results

Illinois

Indiana

Game
Score
ATS
O/U
vs Western Michigan
Sep 13, 2025
W
38-0
W
-27½
U
50½
at Duke
Sep 6, 2025
W
45-19
W
-2½
O
49½
vs Western Illinois
Aug 29, 2025
W
52-3
W
-48½
U
62½
vs South Carolina
Dec 31, 2024
W
21-17
W
+9½
U
50½
at Northwestern
Nov 30, 2024
W
38-28
W
-8½
O
43½
at Rutgers
Nov 23, 2024
W
38-31
W
+2½
O
48
vs Michigan State
Nov 16, 2024
W
38-16
W
-1½
O
47½
vs Minnesota
Nov 2, 2024
L
17-25
L
+3
U
47
at Oregon
Oct 26, 2024
L
9-38
L
+21½
U
54½
vs Michigan
Oct 19, 2024
W
21-7
W
+6
U
44½
Game
Score
ATS
O/U
vs Indiana State
Sep 12, 2025
W
73-0
W
-47½
O
60½
vs Kennesaw State
Sep 6, 2025
W
56-9
W
-35½
O
51½
vs Old Dominion
Aug 30, 2025
W
27-14
L
-23½
U
53½
at Notre Dame
Dec 20, 2024
L
17-27
L
+7
U
50½
vs Purdue
Nov 30, 2024
W
66-0
W
-29½
O
56½
at Ohio State
Nov 23, 2024
L
15-38
L
+10½
O
52½
vs Michigan
Nov 9, 2024
W
20-15
L
-14½
U
47½
at Michigan State
Nov 2, 2024
W
47-10
W
-7½
O
53½
vs Washington
Oct 26, 2024
W
31-17
W
-5½
U
54
vs Nebraska
Oct 19, 2024
W
56-7
W
-6½
O
48
View Full Season Game Log

HEAD TO HEAD

Illinois

ILL

Indiana

IND
Matchup
SU
ATS
O/U
Indiana @ IllinoisNov 11, 2023
45-48
ILL
+4½
IND
44
O
Illinois @ IndianaSep 2, 2022
20-23
IND
0
IND
47½
U
Indiana @ IllinoisNov 11, 2017
24-14
IND
+10½
ILL
52
U

Illinois

UPCOMING SCHEDULE

Indiana

Matchup
Date
Time
vs USC
tvFOX
Sep 27, 2025
12:00 EDT
at Purdue
tvBTN, 610
Oct 4, 2025
12:00 EDT
vs Ohio State
tvFOX
Oct 11, 2025
12:00 EDT
at Washington
tvBTN, 610
Oct 25, 2025
15:30 EDT
vs Rutgers
tvNBC
Nov 1, 2025
12:00 EDT
Matchup
Date
Time
at Iowa
tvPeacock
Sep 27, 2025
15:30 EDT
at Oregon
tvCBS
Oct 11, 2025
15:30 EDT
vs Michigan State
tvPeacock
Oct 18, 2025
15:30 EDT
vs UCLA
tvFOX
Oct 25, 2025
12:00 EDT
at Maryland
tvCBS
Nov 1, 2025
15:30 EDT
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