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FINAL
Sep 27, 2025 12:00 PM EDT
USC 32 vs ILL 34
Week 5
9-4
USC
32
FINAL
34
9-4
#17 Illinois
USC
-7 (+100)o61½ (-125)
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USC Trojans vs Illinois Fighting Illini Odds

Updated:Sep 27, 2025 5:48 AM EDT

Before the much-anticipated clash on September 27, 2025, between the USC Trojans and Illinois Fighting Illini, fans are buzzing with excitement. Taking place at Memorial Stadium in Champaign, IL, this NCAAF game promises thrilling Saturday football action broadcasted live on Fox. The Trojans, favored with a point spread of -7 -105, are looking strong against the Fighting Illini, who are set at +7 -115. For those eyeing the moneyline, the Trojans stand at -250, while the Fighting Illini offer a tempting +205, both available at Caesars. Such odds can be crucial for making informed betting decisions.

As the game approaches, bettors should note the opening odds and current odds shifts. Initially, the point spread was set at -6.5 for the Trojans, indicating a slight shift in favor. These insights can guide your betting strategy, whether you're considering the spread, moneyline, or the total over/under at o61 -110. Ready to leverage these insights? Start your OddsTrader Turbo subscription today or place your bet with a U.S. regulated sportsbook to capitalize on the odds.

For more detailed insights and updates, check our latest NCAAF odds to stay ahead of the game. With the Trojans aiming for dominance and the Fighting Illini ready to challenge, this matchup is set to be a thrilling spectacle for fans and bettors alike.

What is the point spread for the USC Trojans vs Illinois Fighting Illini?
Spread (FULL GAME)
EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE
team
USCSpread
+2.8%
EV
+2.8%
55%
team
IllinoisSpread
-6.0%
EV
-6.0%
45%
MONEYLINE (FULL GAME)
EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE
team
USCMONEYLINE
+6.9%
EV
+6.9%
77%
team
IllinoisMONEYLINE
-10.6%
EV
-10.6%
23%
Total (FULL GAME)
EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE
over
OVERTotal
-3.8%
EV
-3.8%
49%
under
UNDERTotal
+0.4%
EV
+0.4%
53%
Spread (1H)
BEST LINE
team
USCSpread
team
IllinoisSpread
MONEYLINE (1H)
BEST LINE
team
USCMONEYLINE
team
IllinoisMONEYLINE
Total (1H)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (2H)
BEST LINE
team
USCSpread
team
IllinoisSpread
MONEYLINE (2H)
BEST LINE
team
USCMONEYLINE
team
IllinoisMONEYLINE
Total (2H)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (1Q)
BEST LINE
team
USCSpread
team
IllinoisSpread
MONEYLINE (1Q)
BEST LINE
team
USCMONEYLINE
team
IllinoisMONEYLINE
Total (1Q)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (2Q)
BEST LINE
team
USCSpread
team
IllinoisSpread
MONEYLINE (2Q)
BEST LINE
team
USCMONEYLINE
team
IllinoisMONEYLINE
Total (2Q)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (3Q)
BEST LINE
team
USCSpread
team
IllinoisSpread
MONEYLINE (3Q)
BEST LINE
team
USCMONEYLINE
team
IllinoisMONEYLINE
Total (3Q)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (4Q)
BEST LINE
team
USCSpread
team
IllinoisSpread
MONEYLINE (4Q)
BEST LINE
team
USCMONEYLINE
team
IllinoisMONEYLINE
Total (4Q)
BEST LINE
over
OVERTotal
under
UNDERTotal
The best odds available today for USC is -6½ -110 at BetAnything and for Illinois +7 -110 at MyBookie. The total for the over/under line is o61½ -110 at BetAnything.
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