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The highly anticipated match-up between the Indiana Hoosiers and Iowa Hawkeyes is set to take place on September 27, 2025, at Kinnick Stadium in Iowa City, IA. This Saturday football showdown promises to be a thrilling encounter, with the Iowa Hawkeyes eager to capitalize on their home-field advantage. Broadcasting live on Peacock, this NCAAF clash is one you won't want to miss. Our expert picks lean towards a narrow victory for the Hoosiers with a predicted score of 30-21. Historically, the Hoosiers have shown a strong performance, covering the spread in 7 of their last 10 matchups. With a hit rate of 75.2% on the moneyline, Indiana looks promising. The best bet is on Indiana to cover the spread at -8.5. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook for the best odds. For more insights, check out our NCAAF picks page.