Iowa Hawkeyes vs USC Trojans Picks

The upcoming Saturday football game on November 15, 2025, features the Iowa Hawkeyes visiting the USC Trojans at the iconic Los Angeles Memorial Coliseum in Los Angeles, CA. This NCAAF regular season Week 12 matchup promises to deliver exciting action for college football fans and bettors alike. Broadcasted on BTN, this game offers a prime betting opportunity with insightful picks and predictions to help you make smart wagers.

The Iowa Hawkeyes and USC Trojans are set for a competitive clash, with our model predicting a final score of USC 28, Iowa 24. The recommended best bet is the Iowa +6.5 point spread, with a solid 54% hit rate and a positive expected value (EV) of 2.7%. Our prediction model has been profitable in the last 10 games, boasting a high EV and a consistent cover percentage, particularly excelling in point spread markets. This historical success gives bettors confidence in leveraging these picks for a profitable betting experience.

In addition to the point spread, the over 48.5 total points bet is also promising, with a 56.8% hit rate and an EV of 5.6%, predicting a combined score of approximately 53 points. This insight can guide bettors interested in totals markets. For more comprehensive NCAAF picks and betting tips, check out our detailed league predictions NCAAF picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.