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The upcoming clash between the Jackson State Tigers and Southern Miss Golden Eagles on September 6, 2025, promises to be a thrilling encounter in the NCAAF. Scheduled to take place at the iconic M.M. Roberts Stadium in Hattiesburg, MS, this Saturday football game will kick off at 5:00 PM EST. For those eager to catch the action live, it will be broadcasted on ESPN+. The Southern Miss Golden Eagles will be looking to leverage their home advantage, while the Jackson State Tigers aim to upset the hosts. Historically, the Golden Eagles have shown a strong performance at home, but the Tigers have been known to pull off surprises. Our prediction model suggests a close game, with the Southern Miss Golden Eagles edging out the Jackson State Tigers with a predicted score of 27-24. Our picks for this game have been carefully analyzed, and we recommend taking the Southern Miss moneyline as the best bet. Our prediction model has been hitting at a rate of 57% in similar matchups, making this a high EV opportunity. Make sure to check our league picks page for more insights and betting tips. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook for the best odds.