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FINAL
Nov 1, 2025 3:00 PM EDT
LOU 28 vs VT 16
Week 10
9-4
#14 Louisville
28
FINAL
16
3-9
Virginia Tech
LOU
-10 (-116)o52½ (-110)
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Louisville Cardinals vs Virginia Tech Hokies Odds

Updated:Nov 1, 2025 3:22 AM EDT

The upcoming NCAAF clash on November 1, 2025, features the Virginia Tech Hokies hosting the Louisville Cardinals at Lane Stadium in Blacksburg, VA. This Saturday football game is set to be an exciting battle in the 2025-26 season. Fans can catch the action live on The CW, making it easy to follow every play and strategic move.

When it comes to betting, the odds currently favor the Louisville Cardinals as favorites with a point spread of -10½ -110, down from an opening spread of -10 -110. This slight movement suggests growing confidence in Louisville's ability to cover the spread. Meanwhile, the Virginia Tech Hokies are the underdogs at +10½ -110. The over/under total is set at 53½ -110, indicating expectations of a moderately high-scoring game.

Understanding these betting lines can help bettors make smarter decisions. The shift in the point spread odds highlights where the market sees value, and bettors should consider this when placing wagers. For those looking to dive deeper into the betting landscape, the NCAAF odds page offers comprehensive insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

How can I use odds movement to inform my bets?
Spread (FULL GAME)
EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE
team
LouisvilleSpread
-11.0%
EV
-11.0%
42%
team
Virginia TechSpread
+5.8%
EV
+5.8%
59%
MONEYLINE (FULL GAME)
EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE
team
LouisvilleMONEYLINE
-8.4%
EV
-8.4%
70%
team
Virginia TechMONEYLINE
+5.3%
EV
+5.3%
30%
Total (FULL GAME)
EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE
over
OVERTotal
+5.0%
EV
+5.0%
57%
under
UNDERTotal
-13.0%
EV
-13.0%
39%
Spread (1H)
BEST LINE
team
LouisvilleSpread
team
Virginia TechSpread
MONEYLINE (1H)
BEST LINE
team
LouisvilleMONEYLINE
team
Virginia TechMONEYLINE
Total (1H)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (2H)
BEST LINE
team
LouisvilleSpread
team
Virginia TechSpread
MONEYLINE (2H)
BEST LINE
team
LouisvilleMONEYLINE
team
Virginia TechMONEYLINE
Total (2H)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (1Q)
BEST LINE
team
LouisvilleSpread
team
Virginia TechSpread
MONEYLINE (1Q)
BEST LINE
team
LouisvilleMONEYLINE
team
Virginia TechMONEYLINE
Total (1Q)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (2Q)
BEST LINE
team
LouisvilleSpread
team
Virginia TechSpread
MONEYLINE (2Q)
BEST LINE
team
LouisvilleMONEYLINE
team
Virginia TechMONEYLINE
Total (2Q)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (3Q)
BEST LINE
team
LouisvilleSpread
team
Virginia TechSpread
MONEYLINE (3Q)
BEST LINE
team
LouisvilleMONEYLINE
team
Virginia TechMONEYLINE
Total (3Q)
BEST LINE
over
OVERTotal
under
UNDERTotal
Spread (4Q)
BEST LINE
team
LouisvilleSpread
team
Virginia TechSpread
MONEYLINE (4Q)
BEST LINE
team
LouisvilleMONEYLINE
team
Virginia TechMONEYLINE
Total (4Q)
BEST LINE
over
OVERTotal
under
UNDERTotal
The best odds available today for Louisville is -10 -109 at Bookmaker and for Virginia Tech +10½ -108 at Heritage. The total for the over/under line is o52 -113 at Bet105.
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