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FINAL
Sep 20, 2025 11:00 PM EDT
MSU 31 vs USC 45
Week 4
USC
-18½ (-115)o55½ (-110)
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Michigan State vs USC Picks & Predictions
Updated:Sep 20, 2025 5:55 AM EDT
Get ready for a thrilling college football showdown as the Michigan State Spartans take on the USC Trojans on September 20, 2025. This clash, part of the NCAAF season, promises excitement at the Los Angeles Memorial Coliseum in Los Angeles, CA. Both teams are set to showcase their skills, with USC having a slight edge based on recent form. With the game airing on FOX, fans won't want to miss a second of the action.
Our picks suggest a close contest, with USC predicted to win with a score of 36-20. The Trojans, with a coverage percentage of 86.7% for a 2-way bet, are the favorites. However, the Spartans' spread at +18, with a 54% coverage, could offer value for bettors looking for a high EV opportunity. Historically, our predictions have shown a strong hit rate, particularly in American Total markets, where we've had a profitable run.
Our prediction model has been profitable in the last 10 games, with a high EV and cover percentage in several markets. This data can guide you in making informed bets, whether you're considering the over/under market or a point spread. For more detailed insights, visit our NCAAF picks page.
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UPCOMING GAME PREDICTION
Spread
Money
Total
MSUSpread
CONSENSUS LINE
+19 (-110)
PROJECTION
USC (36) - MSU (20)
COVER PROBABILITY
EXPECTED VALUE
+3.6%
BET RATING
SEASON COVER %
0/3
0%
NCAAF
Spread
Game
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- 2H
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Top 25
Top 25
Div. II & III
NCAAFEast-West shrine game
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