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The Nicholls State Colonels are set to face off against the Southeastern Louisiana Lions on November 21, 2025, in a thrilling NCAAF matchup at Strawberry Stadium in Hammond, LA. This Thursday night football event promises exciting action and valuable betting insights for fans and bettors alike, broadcast live on espn+.
Our expert picks predict a strong performance from Southeastern Louisiana with a predicted score of 34, while Nicholls State is expected to score 16. The spread favors Southeastern Louisiana at -20.5, aligning with their recent form. In the last 10 games, our prediction model has shown a solid hit rate in the point spread market, winning 6 out of 10 bets, which indicates a positive expected value for bettors focusing on this market.
For those looking to place smart bets, the analysis of coverage percentages and EV supports Southeastern Louisiana covering the spread. These stats provide bettors with a profitable edge to make informed decisions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more expert insights, visit our NCAAF picks page.
TCU - -6½ -110Bovada | |||||||
![]() Valparaiso - - | |||||||
USC - -35½ -108Heritage | |||||||
![]() Virginia - -3 -110MyBookie | |||||||
![]() North Dakota State - -8½ -105BetOnline | |||||||
Eastern Michigan - -7½ -110Bovada | |||||||
Florida State - -30½ -108Heritage | |||||||
Stanford - -3½ -108Heritage | |||||||
UNLV - -3 -115Bookmaker | |||||||
Rutgers - -30½ -108Heritage | |||||||
![]() Wake Forest - -22½ -108Heritage | |||||||
![]() Kennesaw State - - | |||||||
Buffalo - - | |||||||
![]() Delaware - - | |||||||
UCF - - | |||||||
![]() Georgia Tech - -7 -110BetOnline | |||||||
Minnesota - - | |||||||
![]() Missouri - - | |||||||
Illinois - -27½ -108Heritage | |||||||
![]() Utah - - | |||||||
Eastern Michigan - -3½ -108Heritage | |||||||
Georgia State - - | |||||||
![]() Purdue - - | |||||||
Michigan State - -10½ -105BetOnline | |||||||
![]() Kansas - - | |||||||
USC - -22½ -110BetOnline | |||||||
Stanford - +23 -105BetOnline | |||||||
West Virginia - -17½ -105BetOnline | |||||||
![]() James Madison - -6 -110BetOnline | |||||||
![]() Indiana - -39½ -108Heritage | |||||||
Alabama - -26½ -108Heritage | |||||||
Nebraska - -23½ -105BetOnline | |||||||
![]() Houston - -18½ -108Heritage | |||||||
![]() Connecticut - - | |||||||
Syracuse - - | |||||||
Bowling Green - - | |||||||
Army - - | |||||||
![]() Pittsburgh - -15½ -110Bovada | |||||||
![]() Ohio State - -49½ -110BetOnline | |||||||
![]() South Carolina - -34½ -108Heritage | |||||||
![]() Oklahoma - -40½ -105BetOnline | |||||||
![]() Iowa State - - | |||||||
Kentucky - - | |||||||
Air Force - - | |||||||
Temple - - | |||||||
![]() Georgia - - | |||||||
![]() Cincinnati - -7½ -108Heritage | |||||||
![]() Penn State - -22½ -110BetOnline | |||||||
![]() Duke - -8 -110Bookmaker | |||||||
![]() Texas - -30½ -110BetOnline | |||||||
![]() Oregon - -24½ -108Heritage | |||||||
Auburn - -7 -105Bookmaker | |||||||
Tennessee - - | |||||||
Appalachian State - - | |||||||
![]() Charlotte - - | |||||||
![]() UTSA - - | |||||||
![]() North Dakota State - - | |||||||
Navy - - | |||||||
![]() Tulsa - +12½ -108Heritage | |||||||
Iowa - -30 -110Bookmaker | |||||||
![]() Arkansas - - | |||||||
Southern Miss - - | |||||||
![]() Colorado State - -3½ -108Heritage | |||||||
![]() Old Dominion - - | |||||||
![]() South Florida - -12 -108Heritage | |||||||
Texas A&M - -38½ -110BetOnline | |||||||
Troy - -17 -112Bookmaker | |||||||
![]() Memphis - -10½ -108Heritage | |||||||
![]() South Alabama - - | |||||||
![]() Middle Tennessee - - | |||||||
![]() Kansas State - - | |||||||
![]() Utah State - - | |||||||
![]() Jacksonville State - - | |||||||
![]() Vanderbilt - - | |||||||
![]() Georgia Southern - - | |||||||
![]() Texas Tech - - | |||||||
Rice - - | |||||||
![]() Michigan - -26½ -108Heritage | |||||||
![]() Mississippi State - -28 -110Bookmaker | |||||||
LSU - -11 -110MyBookie | |||||||
Virginia Tech - - | |||||||
![]() Louisiana Tech - - | |||||||
Florida - -26 -110BetOnline | |||||||
![]() Northwestern - - | |||||||
![]() Louisiana - - | |||||||
Maryland - - | |||||||
Brigham Young - - | |||||||
New Mexico State - - | |||||||
![]() Arizona - - | |||||||
San Diego State - - | |||||||
![]() New Mexico - -12 -108Heritage | |||||||
![]() Hawaii - +2½ -110MyBookie | |||||||
![]() Arizona State - - | |||||||
![]() Sacramento State - - | |||||||
![]() California - PK -110BetOnline | |||||||
![]() Nevada - +3½ -115BetOnline | |||||||
![]() Washington - -21½ -108Heritage | |||||||
Notre Dame - -20½ -104Bookmaker | |||||||
![]() Ole Miss - -4½ -110BetOnline | |||||||
Florida State - +3 -115BetOnline |