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The highly anticipated clash between the Ohio State Buckeyes and the Notre Dame Fighting Irish is set to be a thrilling spectacle. Our expert predictions suggest a close contest, with Ohio State favored to win with a predicted score of 27-21. The Buckeyes have a 67.7% chance of covering the spread, making them the best bet for this matchup. The predicted total score is 48.76, slightly favoring the over 45.5 market. For more insights, visit our NCAAF picks page.