USC Trojans vs Oregon Ducks Odds - NCAAF

The upcoming NCAAF clash on November 22, 2025, features the USC Trojans visiting the Oregon Ducks at Autzen Stadium in Eugene, OR. This Saturday football game promises to be a thrilling contest as both teams vie for a key victory in Week 13 of the 2025-26 season.

Currently, the Oregon Ducks are favored with a point spread of -1½ -113, while the USC Trojans are the underdogs at +1½ -107 according to Caesars sportsbook. The opening odds saw a similar spread, but the Ducks' line has shifted 10 points in their favor, indicating increased confidence from bettors and sharp money on Oregon. The total over/under is set at 59½, with the under slightly favored at -112.

Understanding these odds and betting lines is crucial for making a smart wager. The Ducks' favorite status reflects their strong home performance and recent form, while the Trojans' underdog position offers value for bettors looking for an upset. This game will be broadcast on CBS, giving fans and bettors excellent access to watch the action live.

For bettors looking to dive deeper, check out the latest NCAAF odds on our NCAAF odds page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.