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Get ready for some Saturday football action as the Syracuse Orange take on the SMU Mustangs on October 4, 2025, at Gerald J. Ford Stadium in Dallas, TX. This NCAAF showdown is set to be a thrilling encounter, with both teams eager to make a statement. Our picks suggest SMU will come out on top with a predicted score of 37-22, covering the spread of -17.5. Syracuse, however, has shown resilience and could surprise with a closer game than expected. This match will be broadcast on ESPN Networks and ACC Network, so be sure to tune in and catch the excitement live. Our betting tips highlight SMU's strong performance at home, making them a solid choice for your wagers. With a hit rate of 85.3% in their current games, SMU is poised to deliver for bettors. Don't miss out on the action; check out our NCAAF picks page for more insights and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.