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Before the big clash on September 20, 2025, between the SMU Mustangs and TCU Horned Frogs, anticipation is building for this exciting NCAAF matchup. Taking place at the Amon G. Carter Stadium in Fort Worth, TX, fans can catch the action on ESPN2. Our prediction model is calling for a thrilling game, with a predicted score of TCU 36, SMU 26. This places TCU as the favorite with a line of -7, while the over/under sits at 63.5. Our picks suggest that TCU's strong home performance could be the deciding factor. Given the Horned Frogs' recent track record, they have successfully covered the spread in 7 out of their last 10 games, offering a promising hit rate for bettors. With a high EV and proven success in American Total markets, our betting tips favor taking TCU to cover the spread. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more detailed insights and predictions, check out our NCAAF picks page.