Southern Miss Golden Eagles vs South Alabama Jaguars Picks

The upcoming Saturday football game on November 22, 2025, features the Southern Miss Golden Eagles facing off against the South Alabama Jaguars at Hancock Whitney Stadium in Mobile, AL. This NCAAF regular season Week 13 matchup promises an exciting contest for fans and bettors alike, with the game broadcasted on espn+.

Our picks for Southern Miss Golden Eagles vs South Alabama Jaguars lean towards Southern Miss securing a victory with a predicted score of 29 to 26. The prediction model favors Southern Miss on the moneyline with a 59.1% hit rate and a positive EV of 7.6%, indicating a profitable betting opportunity. The point spread also supports Southern Miss +1.5 with a 60.5% hit rate and a 7.0% EV, making it a strong contender for bettors looking to wager on this game.

Over 53.5 is the predicted total score, with a projected total of approximately 54.85 points, suggesting an exciting game with plenty of scoring action. Our American Total market has shown a 52.6% coverage percentage and a modest EV of 0.3%, reinforcing the potential for a high-scoring game. Bettors can use these insights to make informed decisions and potentially maximize their returns.

Historically, our prediction model has been profitable in the last 10 games for similar American Total bets and point spreads, hitting a solid rate that bettors can trust. For those looking to dive deeper into NCAAF betting strategies, our comprehensive NCAAF picks and predictions page is an excellent resource.

Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. The best odds available today for Southern Miss is - at FanDuel and for South Alabama - at FanDuel.