San Francisco Giants vs Arizona Diamondbacks Betting Trends

The Arizona Diamondbacks are set to host the San Francisco Giants on September 17, 2025, at Chase Field in Phoenix, AZ. This MLB matchup promises to be a thrilling encounter, with both teams vying for a crucial win in the regular season. The Diamondbacks will rely on Brandon Pfaadt, their starting pitcher, who boasts a record of 13 wins and 8 losses, a 5.309 ERA, and a 1.4017 WHIP. Pfaadt's performance against right-handed batters will be critical, as the Giants' lineup includes several right-handers. Meanwhile, the Giants will counter with Justin Verlander, a seasoned pitcher with 3 wins and 10 losses, a 3.943 ERA, and a 1.3738 WHIP. Verlander's ability to strike out batters will be key against Arizona's hitters, who have a batting average of .252.

In their recent clash on September 16, 2025, the Diamondbacks edged out the Giants with a 6-5 victory, with Arizona covering the spread. The betting trends suggest a close game, with the odds spread set at -110 for both teams on the moneyline. The over/under is pegged at 9 runs, indicating a potentially high-scoring affair. The Diamondbacks have a strong home record, as highlighted on our MLB standings page.

For bettors looking to make informed decisions, the Diamondbacks' recent form, combined with the Giants' struggles on the road, makes Arizona a favorable pick. Catch the action live on MLB Network and place your bets with a U.S. regulated sportsbook. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.