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Before the Arizona Diamondbacks and San Francisco Giants face off on September 17, 2025, at Chase Field in Phoenix, AZ, let's dive into what bettors need to know. This MLB matchup is set to air on MLB Network, promising an exciting game. Our picks favor Arizona, with a predicted score of 5 to 4 against San Francisco. The Diamondbacks have shown resilience recently, winning 6 of their last 10 games. The Giants have struggled against right-handed pitchers, which could be a key factor in Arizona's favor.
Our prediction model suggests Arizona has a 62.5% chance of winning, making them a strong pick for moneyline bets. The expected total score is around 9.5, leaning slightly towards the over. Betting tips highlight Arizona +1.5 as a less favorable spread option, with a 48.1% coverage probability. However, Arizona's consistent performance at home adds value to this bet.
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CHCK. Hendricks (R) 83-7910 -129BetRivers | |||||||
WSHT. Williams (R) 71-915 +135Caesars | |||||||
NYMT. Megill (R) 75-876 +102FanDuel | |||||||
BOST. Houck (R) 78-8415 -115Caesars | |||||||
ATLJ. Shuster (L) 105-618 -240Caesars | |||||||
TEXM. Pérez (L) 103-761 +135Caesars | |||||||
MILJ. Teheran (R) 92-725 -108BetRivers | |||||||
KCB. Singer (R) 56-1060 +133BetRivers | |||||||
![]() MINJ. Ryan (R) 90-781 -250Caesars | |||||||
HOUJ. France (R) 96-771 -165BetMGM | |||||||
AZZ. Gallen (R) 94-855 -185Bet365 | |||||||
OAKJ. Sears (L) 50-1121 +120Bet365 | |||||||
![]() SDY. Darvish (R) 82-802 -108BetRivers | |||||||
LADUndecided 100-655 -130Caesars | |||||||
SEAB. Woo (R) 88-743 -130Caesars |
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