Boston Red Sox Vs Tampa Bay Rays Picks

The highly anticipated MLB matchup between the Boston Red Sox and the Tampa Bay Rays is set to take place on September 21, 2025, at George M. Steinbrenner Field in Tampa, FL. This game is sure to be a thrilling spectacle for baseball fans and bettors alike. As the Red Sox take on the Rays, viewers can tune in to NESN to catch all the action. Boston comes into this game with a strong track record, having won their last match against Tampa Bay on September 20, 2025. Our prediction model gives the Red Sox a 60.8% chance to win, with an expected score of 4.53 to 3.51 in favor of Boston. We recommend betting on the Red Sox to win, as their hitters have performed well against right-handed pitchers, which should give them an edge over Tampa Bay's pitching staff. For those looking for a high EV bet, the point spread market offers a 55% chance of Tampa Bay covering the +1.5 spread. Our American Total predictions suggest a total score of 8, with a 54.7% chance of the game staying under this total. Our predictions have shown a profitable hit rate, particularly in the 2-way market, winning 6 out of the last 10 games. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more insights, visit our MLB picks page.